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Review
. 2025 May 30:16:1561688.
doi: 10.3389/fphar.2025.1561688. eCollection 2025.

Traditional, complementary, and integrative medicine in the management of ischemic stroke: a narrative review

S Sowmiya  1 , Rukaiah Fatma Begum  2 , L S Dhivya  3 , Praveen Rajendran  1 , N Harikrishnan  4 , Ankul Singh S  1
Affiliations
Review

Traditional, complementary, and integrative medicine in the management of ischemic stroke: a narrative review

S Sowmiya et al. Front Pharmacol. .

Abstract

Ischemic stroke remains a leading cause of mortality and long-term disability worldwide, despite advancements in acute intervention and rehabilitation strategies. Traditional, Complementary, and Integrative Medicine (TCIM) systems; including herbal medicine, acupuncture, and mind-body interventions are increasingly being explored as adjunct therapies in stroke management. This narrative review evaluates the current evidence supporting TCIM approaches for ischemic stroke, highlighting their potential neuroprotective, anti-inflammatory, antioxidant, and cerebrovascular effects. Particular emphasis is placed on well-studied botanical interventions such as Salvia miltiorrhiza Bunge [Lamiaceae; Salviae miltiorrhizae radix et rhizoma], Ginkgo biloba L. [Ginkgoaceae; Ginkgo folium], and Panax ginseng C.A. Mey. [Araliaceae; Ginseng radix]. The review discusses the mechanisms of action, clinical trial outcomes, and integration challenges, while underscoring the need for standardization, quality control, and rigorous scientific validation. This work aims to support informed decisions regarding the integration of evidence-based TCIM practices into conventional stroke care protocols.

Keywords: and integrative medicine; complementary; complementary alternative medicine; ischemic stroke; neuroinflammation; oxidative stress; traditional.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Pathophysiology of ischemia Stroke.
See this image and copyright information in PMC

References

    1. Abdelsalam S. A., Renu K., Zahra H. A., Abdallah B. M., Ali E. M., Veeraraghavan V. P., et al. (2023). Polyphenols mediate neuroprotection in cerebral ischemic stroke—an update. Nutrients 15, 1107. 10.3390/nu15051107 - DOI - PMC - PubMed
    1. Ajoolabady A., Wang S., Kroemer G., Penninger J. M., Uversky V. N., Pratico D., et al. (2021). Targeting autophagy in ischemic stroke: from molecular mechanisms to clinical therapeutics. Pharmacol. Ther. 225, 107848. 10.1016/j.pharmthera.2021.107848 - DOI - PMC - PubMed
    1. Akashlal M., Nair P.P., Nair D.R., Ahmad A., Chandrasekhararao B., Sudhakar D. (2025). A systematic review on safety and efficacy of ayurvedic interventions in hemiplegia (pakshaghata). J. Evid. Based Integr. Med. 30, 2515690X241304523. 10.1177/2515690X241304523 - DOI - PMC - PubMed
    1. Ara I., Maqbool M., Gani I., Kashmir O., Kashmir I. (2022). Neuroprotective activity of herbal medicinal products: a review. Int. J. Cyrrent Reseach Physiology Pharmacol. 6. Available online at: https://ijcrpp.com/index.php/ijcrpp/article/view/53 .
    1. Barclay R. E., Stevenson T. J., Poluha W., Semenko B., Schubert J. (2020). Mental practice for treating upper extremity deficits in individuals with hemiparesis after stroke. Cochrane Database Syst. Rev. 2020. 10.1002/14651858.cd005950.pub5 - DOI - PMC - PubMed

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