Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 May;12(3):035002.
doi: 10.1117/1.JMI.12.3.035002. Epub 2025 Jun 12.

LED-based, real-time, hyperspectral imaging device

Naeeme Modir  1   2 , Maysam Shahedi  1 , James Dormer  1 , Ling Ma  1   2 , Baowei Fei  1   2   3
Affiliations

LED-based, real-time, hyperspectral imaging device

Naeeme Modir et al. J Med Imaging (Bellingham). 2025 May.

Abstract

Purpose: This study demonstrates the feasibility of using an LED array for hyperspectral imaging (HSI). The prototype validates the concept and provides insights into the design of future HSI applications. Our goal is to design, develop, and test a real-time, LED-based HSI prototype as a proof-of-principle device for in situ hyperspectral imaging using LEDs.

Approach: A prototype was designed based on a multiwavelength LED array and a monochrome camera and was tested to investigate the properties of the LED-based HSI. The LED array consisted of 18 LEDs in 18 different wavelengths from 405 nm to 910 nm. The performance of the imaging system was evaluated on different normal and cancerous ex vivo tissues. The impact of imaging conditions on the HSI quality was investigated. The LED-based HSI device was compared with a reference hyperspectral camera system.

Results: The hyperspectral signatures of different imaging targets were acquired using our prototype HSI device, which are comparable to the data obtained using the reference HSI system.

Conclusions: The feasibility of employing a spectral LED array as the illumination source for high-speed and high-quality HSI has been demonstrated. The use of LEDs for HSI can open the door to numerous applications in endoscopic, laparoscopic, and handheld HSI devices.

Keywords: FPGA; LED array; endoscope; gastrointestinal cancer; hyperspectral imaging; multispectral imaging.

PubMed Disclaimer

References

    1. Siegel R. L., Giaquinto A. N., Jemal A., “Cancer statistics, 2024,” CA Cancer J. Clin. 74(1), 12–49 (2024). 10.3322/caac.21820 - DOI - PubMed
    1. Choi K. S., et al. , “Effect of endoscopy screening on stage at gastric cancer diagnosis: results of the National Cancer Screening Programme in Korea,” Br. J. Cancer 112(3), 608–612 (2015). 10.1038/bjc.2014.608 - DOI - PMC - PubMed
    1. Chadwick G., et al. , “Gastric cancers missed during endoscopy in England,” Clin. Gastroenterol. Hepatol. 13(7), 1264–1270.e1 (2015). 10.1016/j.cgh.2015.01.025 - DOI - PubMed
    1. Menon S., Trudgill N., “How commonly is upper gastrointestinal cancer missed at endoscopy? A meta-analysis,” Endosc. Int. Open 2(2), E46–E50 (2014). 10.1055/s-0034-1365524 - DOI - PMC - PubMed
    1. Lu G., Fei B., “Medical hyperspectral imaging: a review,” J. Biomed. Opt. 19(1), 010901 (2014). 10.1117/1.JBO.19.1.010901 - DOI - PMC - PubMed

LinkOut - more resources