Targeting Extramedullary Hematopoiesis and Cardiac Immune Homing to Encourage Cardiac Healing After Myocardial Infarction

Ebin Johny¹, Partha Dutta^{2

3

4

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Affiliations

¹ Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute (E.J.), University of Pittsburgh, PA.
² Department of Bioengineering, Swanson School of Engineering (P.D.), University of Pittsburgh, PA.
³ Division of Cardiology, Department of Medicine (P.D.), University of Pittsburgh, PA.
⁴ Department of Immunology, University of Pittsburgh School of Medicine, PA (P.D.).
⁵ Pittsburgh VA Medical Center, PA (P.D.).

Editorial

Ebin Johny et al. Circulation. 2025.

. 2025 Jun 17;151(24):1748-1751.

doi: 10.1161/CIRCULATIONAHA.125.074786. Epub 2025 Jun 16.

Ebin Johny¹, Partha Dutta^{2

3

4

5}

¹ Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute (E.J.), University of Pittsburgh, PA.
² Department of Bioengineering, Swanson School of Engineering (P.D.), University of Pittsburgh, PA.
³ Division of Cardiology, Department of Medicine (P.D.), University of Pittsburgh, PA.
⁴ Department of Immunology, University of Pittsburgh School of Medicine, PA (P.D.).
⁵ Pittsburgh VA Medical Center, PA (P.D.).

No abstract available

Keywords: Editorials; cardiac remodeling; hematopoiesis; myocardial infarction; spleen.

Conflict of interest statement

None.

Suppression of the Prostaglandin I2-Type 1 Interferon Axis Induces Extramedullary Hematopoiesis to Promote Cardiac Repair After Myocardial Infarction.
Lv H, Wang C, Liu Z, Quan M, Li K, Gou F, Shi X, Liu Q, Yu Y, Zhu P, Cheng H, Cheng T, Ai D. Lv H, et al. Circulation. 2025 Jun 17;151(24):1730-1747. doi: 10.1161/CIRCULATIONAHA.124.069420. Epub 2025 Apr 28. Circulation. 2025. PMID: 40289806
Splenic CD169⁺Tim4⁺ Marginal Metallophilic Macrophages Are Essential for Wound Healing After Myocardial Infarction.
Ismahil MA, Zhou G, Rajasekar S, Gao M, Bansal SS, Patel B, Limdi N, Xie M, Antipenko S, Rokosh G, Hamid T, Prabhu SD. Ismahil MA, et al. Circulation. 2025 Jun 17;151(24):1712-1729. doi: 10.1161/CIRCULATIONAHA.124.071772. Epub 2025 Apr 28. Circulation. 2025. PMID: 40289811 Free PMC article.

1. Leuschner F, Rauch PJ, Ueno T, Gorbatov R, Marinelli B, Lee WW, Dutta P, Wei Y, Robbins C, Iwamoto Y, Sena B, Chudnovskiy A, Panizzi P, Keliher E, Higgins JM, Libby P, Moskowitz MA, Pittet MJ, Swirski FK, Weissleder R and Nahrendorf M. Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis. J Exp Med. 2012;209:123–37. - PMC - PubMed
1. Prabhu SD and Frangogiannis NG. The biological basis for cardiac repair after myocardial infarction: from inflammation to fibrosis. Circulation research. 2016;119:91–112. - PMC - PubMed
1. Lv HW C; Liu Z; Quan M; Li K; Gou F; Shi X; Liu Q; Yu Q; Yu Y; Zhu P; Cheng H; Cheng T; Ai Ding. Suppression of prostaglandin I2–type I interferon 1 axis induces extramedullary hematopoiesis to promote cardiac repair after myocardial infarction. Circulation. 2025. - PubMed
1. Ismahil MZ G; Rajasekar S; Gao M; Bansal SS; Patel B; Limdi N; Xie M; Antipenko S; Rokosh G; Hamid T; Prabhu SD. Splenic CD169+Tim4+ Marginal Metallophilic Macrophages Are Essential for Wound Healing After Myocardial Infarction. Circulation. 2025. - PMC - PubMed
1. Robbins CS, Chudnovskiy A, Rauch PJ, Figueiredo JL, Iwamoto Y, Gorbatov R, Etzrodt M, Weber GF, Ueno T, van Rooijen N, Mulligan-Kehoe MJ, Libby P, Nahrendorf M, Pittet MJ, Weissleder R and Swirski FK. Extramedullary hematopoiesis generates Ly-6C(high) monocytes that infiltrate atherosclerotic lesions. Circulation. 2012;125:364–74. - PMC - PubMed