Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Jun 17;40(1):287.
doi: 10.1007/s10103-025-04518-4.

Clinical observation of pyogenic granuloma treated with combined long-pulse 1064nm Nd: YAG laser and pulsed CO2 laser photodynamic therapy

Xueyang Zhang  1 , Na Li  1 , Congmin Wang  2 , Junhong Ao  1 , Zhen Yuan  1 , Zixuan Qi  1 , Xiaomin Xu  1 , Aiqin Li  3 , Yujia Wang  4
Affiliations

Clinical observation of pyogenic granuloma treated with combined long-pulse 1064nm Nd: YAG laser and pulsed CO2 laser photodynamic therapy

Xueyang Zhang et al. Lasers Med Sci. .

Abstract

To explore the clinical efficacy and safety of long-pulse 1064nm Nd: YAG laser combined with pulsed CO2 laser and topical application of aminolevulinic acid hydrochloride for photodynamic therapy in treating pyogenic granuloma. 20 patients with pyogenic granuloma were treated with a combination of long-pulse 1064nm Nd: YAG laser and pulsed CO2 laser along with photodynamic therapy using aminolevulinic acid hydrochloride. The efficacy, recurrence rate, and safety were observed at 1 month and 2 months post-treatment. All patients achieved a 100%cure rate and total effectiveness with a single treatment, with no infections, ulcers, or scars observed. Eight patients experienced mild pigmentation, which gradually resolved within one month, and there were no recurrences. The combined therapy of long-pulse 1064nm Nd: YAG laser and pulsed CO2 laser with photodynamic therapy is highly effective in treating pyogenic granuloma, with no recurrences and minimal adverse reactions, significantly improving patient satisfaction.

Keywords: Long-pulse 1064nm Nd; Photodynamic therapy; Pulsed CO2 laser; Pyogenic granuloma; YAG laser.

PubMed Disclaimer

Conflict of interest statement

Declarations. This study complies with the principles of the Declaration of Helsinki and the relevant ethical requirements, waiver of informed consent was applied for and passed. The clinical trial in this study (S2025-009–01) was examined and approved by the SGS Ethics Committee. Competing interests: The authors declare no competing interests. Clinical trial number: Not applicable because this study was a retrospective analysis, there was no financial support.

References

    1. Park SH, Lee JH, Tak MS et al (2017) A research of pyogenic granuloma genesis factor with immunohistochemical analysis[J]. J Craniofac Surg 28(8):2068–2072. https://doi.org/10.1097/SCS.0000000000004148 - DOI - PubMed
    1. Xu YD, Li W (2018) Advances in the diagnosis and treatment of pyogenic granuloma[J]. Chinese J Plast Surg 34(11):981–984
    1. Zhao B (2009) Clinical dermatology in China[M]. Jiangsu Science and Technology Publishing House, Nanjing, p 1608
    1. Liang N, Fan W, Cao Y et al (2017) Clinical observation of 60 cases treated with fractional CO2 laser combined with high-frequency electrocoagulation for pyogenic granuloma[J]. Prac J Dermatol 10(5):274–276
    1. Kaleeny JD, Janis JE (2024) Pyogenic granuloma diagnosis and management: a practical review [J]. Plast Reconstr Surg Glob Open 12(9):e6160 - DOI - PubMed - PMC

Substances

LinkOut - more resources