Long-term changes in Sjögren's disease: a 9-year prospective follow-up study from the SJOGRENSER Registry

Mónica Fernández-Castro¹, Zulema Plaza-Almuedo², Jose Rosas³, Victor Martínez-Taboada⁴, Alejandro Olivé⁵, Raúl Menor-Almagro⁶, Belen Serrano-Benavente⁷, Judit Font-Urgelles⁵, Angel García-Aparicio⁸, Sara Manrique-Arija⁹, Jesus Alberto García-Vadillo^{10

11}, Ruth López-González¹², Javier Narváez¹³, Beatriz Rodriguez-Lozano¹⁴, Carlos Galisteo¹⁵, Jorge González-Martín¹⁶, Paloma Vela-Casasempere¹⁷, Cristina Bohórquez¹⁸, Celia Erausquin¹⁹, Beatriz Paredes-Romero²⁰, Leyre Riancho-Zarrabeitia²¹, Sheila Melchor-Diaz²², Jose Maria Pego-Reigosa²³, Sergi Heredia²⁴, Clara Moriano²⁵, Maria Angeles Blazquez-Cañamero²⁶, Paula Estrada²⁷, Enrique Júdez²⁸, Joaquín María Belzunegui²⁹, Consuelo Ramos³⁰, Fernando Sánchez-Alonso², Jose Luis Andreu³¹; Systemic Autoimmune Diseases Group of the Spanish Society of Rheumatology (EAS-SER)

Affiliations

¹ Rheumatology department, Puerta de Hierro Majadahonda University Hospital, Madrid, Spain. monfercas@yahoo.es.
² Research Unit, Spanish Society of Rheumatology, Madrid, Spain.
³ Rheumatology Deparment, Hospital Marina Baixa de La Vila Joiosa, Alicante, Spain.
⁴ Rheumatology department, Marqués de Valdecilla-IDIVAL University Hospital, University of Cantabria, Santander, Spain.
⁵ Rheumathology Hospital Universitario Germans Trías i Pujol, Badalona, Barcelona, Spain.
⁶ Rheumatology department, H. General Universitario Jerez de la Frontera, Jerez de la Frontera, Spain.
⁷ Rheumatology department, Hospital Gregorio Marañon, Madrid, Spain.
⁸ Rheumatology department, Hospital Universitario de Toledo, Toledo, Spain.
⁹ Rheumatology department, Malaga Regional Hospital, Málaga, Spain.
¹⁰ Rheumatology department, Hospital Universitario La Princesa, Madrid, Spain.
¹¹ Sociedad Española de Reumatología, Sociedad Española de Reumatología, Madrid, Spain.
¹² Rheumatology department, Zamora Health Complex, Zamora University, Zamora, Spain.
¹³ Rheumatology department, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
¹⁴ Rheumatology department, Canarias University Hospital, San Cristóbal de La Laguna, Spain.
¹⁵ Rheumatology department, Hospital Parc Taulí, Sabadell, Spain.
¹⁶ Rheumatology department, HM Sanchinarro Univeristary Hospital, Madrid, Spain.
¹⁷ Rheumatology department, General University Hospital Dr. Balmis Alicante, Miguel Hernández University, Alicante, Spain.
¹⁸ Rheumatology department, Príncipe de Asturias University Hospital, Alcalá de Henares University, Madrid, Spain.
¹⁹ Rheumatology department, Dr Negrin University Hospital, Las Palmas, Spain.
²⁰ Rheumatology department, Infanta Sofía University Hospital, San Sebastián de los Reyes, Madrid, Spain.
²¹ Rheumatology department, Sierrallana Hospital, IDIVAL, Santander, Spain.
²² Rheumatology department, 12 de Octubre University Hospital, Madrid, Spain.
²³ Rheumatology department, University Hospital of Vigo IRIDIS-VIGO Group, Vigo, Spain.
²⁴ Rheumatology department, Complex Hospitalari Moisès Broggi, Barcelona, Spain.
²⁵ Rheumatology department, León University Hospital, León, Spain.
²⁶ Rheumatology department, Ramón y Cajal University Hospital, Madrid, Spain.
²⁷ Rheumatology department, Complex Universitari Hospital Moisès Broggi, Sant Joan Despí, Barcelona, Spain.
²⁸ Rheumatology department, Albacete University Hospital, Albacete, Spain.
²⁹ Rheumatology department, Donostia University Hospital, Donostia, Spain.
³⁰ Rheumatology department, Valme University Hospital, Sevilla, Spain.
³¹ Rheumatology department, Puerta de Hierro Majadahonda University Hospital, Madrid, Spain.

PMID: 40526294
DOI: 10.1007/s00296-025-05909-0

Observational Study

Long-term changes in Sjögren's disease: a 9-year prospective follow-up study from the SJOGRENSER Registry

Mónica Fernández-Castro et al. Rheumatol Int. 2025.

. 2025 Jun 17;45(7):156.

doi: 10.1007/s00296-025-05909-0.

Authors

Affiliations

¹ Rheumatology department, Puerta de Hierro Majadahonda University Hospital, Madrid, Spain. monfercas@yahoo.es.
² Research Unit, Spanish Society of Rheumatology, Madrid, Spain.
³ Rheumatology Deparment, Hospital Marina Baixa de La Vila Joiosa, Alicante, Spain.
⁴ Rheumatology department, Marqués de Valdecilla-IDIVAL University Hospital, University of Cantabria, Santander, Spain.
⁵ Rheumathology Hospital Universitario Germans Trías i Pujol, Badalona, Barcelona, Spain.
⁶ Rheumatology department, H. General Universitario Jerez de la Frontera, Jerez de la Frontera, Spain.
⁷ Rheumatology department, Hospital Gregorio Marañon, Madrid, Spain.
⁸ Rheumatology department, Hospital Universitario de Toledo, Toledo, Spain.
⁹ Rheumatology department, Malaga Regional Hospital, Málaga, Spain.
¹⁰ Rheumatology department, Hospital Universitario La Princesa, Madrid, Spain.
¹¹ Sociedad Española de Reumatología, Sociedad Española de Reumatología, Madrid, Spain.
¹² Rheumatology department, Zamora Health Complex, Zamora University, Zamora, Spain.
¹³ Rheumatology department, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
¹⁴ Rheumatology department, Canarias University Hospital, San Cristóbal de La Laguna, Spain.
¹⁵ Rheumatology department, Hospital Parc Taulí, Sabadell, Spain.
¹⁶ Rheumatology department, HM Sanchinarro Univeristary Hospital, Madrid, Spain.
¹⁷ Rheumatology department, General University Hospital Dr. Balmis Alicante, Miguel Hernández University, Alicante, Spain.
¹⁸ Rheumatology department, Príncipe de Asturias University Hospital, Alcalá de Henares University, Madrid, Spain.
¹⁹ Rheumatology department, Dr Negrin University Hospital, Las Palmas, Spain.
²⁰ Rheumatology department, Infanta Sofía University Hospital, San Sebastián de los Reyes, Madrid, Spain.
²¹ Rheumatology department, Sierrallana Hospital, IDIVAL, Santander, Spain.
²² Rheumatology department, 12 de Octubre University Hospital, Madrid, Spain.
²³ Rheumatology department, University Hospital of Vigo IRIDIS-VIGO Group, Vigo, Spain.
²⁴ Rheumatology department, Complex Hospitalari Moisès Broggi, Barcelona, Spain.
²⁵ Rheumatology department, León University Hospital, León, Spain.
²⁶ Rheumatology department, Ramón y Cajal University Hospital, Madrid, Spain.
²⁷ Rheumatology department, Complex Universitari Hospital Moisès Broggi, Sant Joan Despí, Barcelona, Spain.
²⁸ Rheumatology department, Albacete University Hospital, Albacete, Spain.
²⁹ Rheumatology department, Donostia University Hospital, Donostia, Spain.
³⁰ Rheumatology department, Valme University Hospital, Sevilla, Spain.
³¹ Rheumatology department, Puerta de Hierro Majadahonda University Hospital, Madrid, Spain.

PMID: 40526294
DOI: 10.1007/s00296-025-05909-0

Abstract

The objective of SjögrenSER Prospective (SjD-PROS) was to evaluate the improvement, stability or progression of SjD in clinical practice. SjD-PROS is an observational, longitudinal, multicenter study of SjD in Spain. Participants from the prior transversal phase were invited to a follow-up visit after 9.5 years. Data were collected via interviews and medical records. Variables were analyzed using means, medians and frequencies. Statistical associations were assessed using T student test, Kruskal-Wallis and the Chi-square test. We included 314 patients, 95% women (mean age of 66 years; mean disease duration of 17 years). At follow-up visit, the most frequent systemic manifestations were arthralgias (54%) and hematological involvement (49%), with arthralgias being significantly less frequent than at baseline visit (p < 0.001); the most affected organs were the lung (15.6%) and the kidney (11.5%). Half of the patients in SjD-PROS, had positive rheumatoid factor, 16% less than at baseline visit; β2-microglobulin was significantly elevated compared to baseline visit (62.5%, p < 0.001). Articular, pulmonary, hematological and biological domains of ESSDAI index showed the greatest changes, both in improvement and worsening, and the greatest activity. Systemic treatments use was significantly higher in patients showing activity in ESSDAI. This study offers valuable insights into the most variable clinical and serological manifestations throughout the course of SjD. ESSDAI domains showing the greatest changes reflected the greatest treatments needs. These findings allow for patient stratification based on phenotype, a crucial step in designing follow-up protocols.

Keywords: Activity index; Serological tests; Sjögren’s syndrome; Symptom assessment; Systemic involvement; Treatment.

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References

1. Parisis D, Chivasso C, Perret J, Soyfoo MS, Delporte C (2020) Current state of knowledge on primary Sjögren’s syndrome, an autoimmune exocrinopathy. J Clin Med 9:2299. https://doi.org/10.3390/jcm9072299 - DOI - PubMed - PMC
1. Mariette X, Criswell LA (2018) Primary Sjögren’s syndrome. N Engl J Med 378:931–939. https://doi.org/10.1056/NEJMcp1702514 - DOI - PubMed
1. Longhino S, Chatzis LG, Dal Pozzolo R, Perreti S, Fulvio G, La Rocca G, Navarro Garcia IC, Orlandi M, Quartuccio L, Baldini C, Bartolini E (2023) Sjögren’s syndrome: one year in review 2023. Clin Exp Rheumatol 41:2343–2356. https://doi.org/10.55563/clinexprheumatol/255qsx - DOI - PubMed
1. Narváez J, Sánchez-Fernández SA, Seoane-Mato D, Díaz-González F, Bustabad S (2020) Prevalence of Sjögren’s syndrome in the general adult population in Spain: estimating the proportion of undiagnosed cases. Sci Rep 10:10627. https://doi.org/10.1038/s41598-020-67462-z - DOI - PubMed - PMC
1. Beydon M, McCoy S, Nguyen Y, Sumida T, Mariette X, Seror R (2024) Epidemiology of Sjögren syndrome. Nat Rev Rheumatol 20:158–169. https://doi.org/10.1038/s41584-023-01057-6 - DOI - PubMed

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Long-term changes in Sjögren's disease: a 9-year prospective follow-up study from the SJOGRENSER Registry

Affiliations

Long-term changes in Sjögren's disease: a 9-year prospective follow-up study from the SJOGRENSER Registry

Authors

Affiliations

Abstract

References

Publication types

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LinkOut - more resources

Full Text Sources

Medical

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