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. 2025 Jun 17:dc242023.
doi: 10.2337/dc24-2023. Online ahead of print.

Role of Adipose Tissue Compartments for Cardiovascular Risk in Diabetes Endotypes

Oana-Patricia Zaharia  1   2   3 , Yuliya Kupriyanova  2   3 , Pavel Bobrov  2   4 , Christian Binsch  1   2   3 , Birgit Knebel  2   5 , Tim Mori  2   4 , Iryna Yurchenko  2   3 , Dania Marel Mendez Cardenas  2   3 , Theresa Kössler  1   2   3 , Nina Trinks  2   3 , Martin Schön  1   2   3 , Kálmán B Bódis  1   2   3 , Robert Wagner  1   2   3 , Vera Schrauwen-Hinderling  2   3 , Michael Roden  1   2   3 ; GDS Group
Collaborators, Affiliations

Role of Adipose Tissue Compartments for Cardiovascular Risk in Diabetes Endotypes

Oana-Patricia Zaharia et al. Diabetes Care. .

Abstract

Objective: The severe insulin-resistant diabetes (SIRD) endotype is associated with metabolic dysfunction-associated steatotic liver disease and higher cardiovascular risk. We investigated whether skeletal muscle or adipose tissue lipids are elevated in SIRD.

Research design and methods: Participants (N = 420) of the German Diabetes Study (GDS) were assigned to diabetes clusters using a validated algorithm. 1H-magnetic resonance methods were used to quantify intramyocellular lipids (IMCLs), intrahepatic lipids (IHLs), and visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) volumes.

Results: Aside from elevated IHLs (P < 0.01), SIRD showed higher VAT and SAT than other endotypes after adjustment for BMI (all P < 0.05) but not for multiple comparisons. All endotypes featured comparable IMCLs. VAT volume and IHLs correlated with cardiovascular risk scores (Framingham r = 0.661 and 0.548, respectively, P < 0.05). Polygenic risk scores for VAT were associated with higher cardiovascular risk.

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