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Review
. 2025 Jul;55(4):512-525.
doi: 10.1053/j.semnuclmed.2025.06.002. Epub 2025 Jun 16.

Neuroimaging of Mild Traumatic Injury

Gabriela Capriotti  1 , Alessia Guarnera  2 , Andrea Romano  2 , Giulia Moltoni  2 , Giorgia Granese  3 , Alessando Bozzao  2 , Alberto Signore  3
Affiliations
Free article
Review

Neuroimaging of Mild Traumatic Injury

Gabriela Capriotti et al. Semin Nucl Med. 2025 Jul.
Free article

Abstract

Traumatic brain injury (TBI) is a global public health problem and is a leading cause of disability, morbidity and death in children and adults in USA It is characterised by alteration of neurological, behavioral and cognitive function as consequence of biomechanical insulte and possible progression to chronic encephalopathy. According to the CDC, approximately 75% of all reported TBIs are considered mild in form. Mild TBI is defined as individuals who had head trauma with subsequent mild deficit on the GCS and thu are frequently observed in military combat, athletes and motor vehicle accidents. Clinical assessment of mTBI is difficult and therefore different neuroimaging techniques have been used to characterized different stages of the disease. This article reviews the utility of imaging while focusing on the emerging applications of advanced MRI studies and PET in TBI.

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Conflict of interest statement

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Alberto Signore reports administrative support was provided by University of Rome La Sapienza. Gabriela Capriotti reports a relationship with University of Rome La Sapienza that includes: employment. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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