Skin health and biological aging

David Furman^{1

2

3

4}, Johan Auwerx^{5

6}, Anne-Laure Bulteau⁷, George Church^{5

8

9}, Virginie Couturaud¹⁰, Laure Crabbe⁷, Kelvin J A Davies^{5

11

12}, Anabelle Decottignies^{5

13}, Vadim N Gladyshev^{5

14}, Brian K Kennedy^{5

15

16}, Nicola Neretti^{5

17}, Carine Nizard⁷, Karl Pays⁷, Daisy Robinton^{5

18}, Vittorio Sebastiano^{5

19}, Rachel E B Watson²⁰, Meng C Wang^{5

21}, Knut Woltjen^{5

22}

Affiliations

¹ Stanford 1000 Immunomes Project, Stanford School of Medicine, Stanford, CA, USA. dfurman@buckinstitute.org.
² Buck Bioinformatics and Data Science Platform, Buck Institute for Research on Aging, Novato, CA, USA. dfurman@buckinstitute.org.
³ IIMT, Universidad Austral, Consejo Nacional de Investigaciones Científicas y Técnicas, Pilar, Argentina. dfurman@buckinstitute.org.
⁴ Reverse Aging Board, Parfums Christian Dior, Neuilly-sur-Seine, France. dfurman@buckinstitute.org.
⁵ Reverse Aging Board, Parfums Christian Dior, Neuilly-sur-Seine, France.
⁶ Laboratory of Integrative Systems Physiology, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
⁷ LVMH Recherche, Saint Jean de Braye, France.
⁸ Wyss Institute for Biologically Inspired Engineering, Boston, MA, USA.
⁹ Department of Genetics, Harvard Medical School, Boston, MA, USA.
¹⁰ Department of Scientific Communication, Parfum Christian Dior, Neuilly sur Seine, France.
¹¹ Leonard Davis School of Gerontology; and Division of Molecular & Computational Biology, Department of Biological Sciences of the College of Letters, Arts & Sciences, University of Southern California, Los Angeles, CA, USA.
¹² Department of Biochemistry & Molecular Medicine of the Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.
¹³ Université Catholique de Louvain, de Duve Institute, Louvain-la-Neuve, Belgium.
¹⁴ Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
¹⁵ Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
¹⁶ Centre for Healthy Longevity, National University Health System, Singapore, Singapore.
¹⁷ Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI, USA.
¹⁸ Oviva Therapeutics, Brooklyn, NY, USA.
¹⁹ Institute for Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford, CA, USA.
²⁰ A*STAR Skin Research Labs (A*SRL), Agency for Science, Technology and Research (A*STAR), National Skin Centre & Skin Research Institute of Singapore (SRIS), Singapore, Republic of Singapore.
²¹ HHMI Janelia Research Campus, Ashburn, VA, USA.
²² Kyoto University, Yoshidahonmachi, Sakyo Ward, Kyoto, Japan.

PMID: 40527938
DOI: 10.1038/s43587-025-00901-6

Review

Skin health and biological aging

David Furman et al. Nat Aging. 2025 Jul.

. 2025 Jul;5(7):1195-1206.

doi: 10.1038/s43587-025-00901-6. Epub 2025 Jun 17.

Authors

Affiliations

¹ Stanford 1000 Immunomes Project, Stanford School of Medicine, Stanford, CA, USA. dfurman@buckinstitute.org.
² Buck Bioinformatics and Data Science Platform, Buck Institute for Research on Aging, Novato, CA, USA. dfurman@buckinstitute.org.
³ IIMT, Universidad Austral, Consejo Nacional de Investigaciones Científicas y Técnicas, Pilar, Argentina. dfurman@buckinstitute.org.
⁴ Reverse Aging Board, Parfums Christian Dior, Neuilly-sur-Seine, France. dfurman@buckinstitute.org.
⁵ Reverse Aging Board, Parfums Christian Dior, Neuilly-sur-Seine, France.
⁶ Laboratory of Integrative Systems Physiology, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
⁷ LVMH Recherche, Saint Jean de Braye, France.
⁸ Wyss Institute for Biologically Inspired Engineering, Boston, MA, USA.
⁹ Department of Genetics, Harvard Medical School, Boston, MA, USA.
¹⁰ Department of Scientific Communication, Parfum Christian Dior, Neuilly sur Seine, France.
¹¹ Leonard Davis School of Gerontology; and Division of Molecular & Computational Biology, Department of Biological Sciences of the College of Letters, Arts & Sciences, University of Southern California, Los Angeles, CA, USA.
¹² Department of Biochemistry & Molecular Medicine of the Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.
¹³ Université Catholique de Louvain, de Duve Institute, Louvain-la-Neuve, Belgium.
¹⁴ Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
¹⁵ Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
¹⁶ Centre for Healthy Longevity, National University Health System, Singapore, Singapore.
¹⁷ Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI, USA.
¹⁸ Oviva Therapeutics, Brooklyn, NY, USA.
¹⁹ Institute for Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford, CA, USA.
²⁰ A*STAR Skin Research Labs (A*SRL), Agency for Science, Technology and Research (A*STAR), National Skin Centre & Skin Research Institute of Singapore (SRIS), Singapore, Republic of Singapore.
²¹ HHMI Janelia Research Campus, Ashburn, VA, USA.
²² Kyoto University, Yoshidahonmachi, Sakyo Ward, Kyoto, Japan.

PMID: 40527938
DOI: 10.1038/s43587-025-00901-6

Abstract

Accumulating evidence indicates that biological aging can be accelerated by environmental exposures, collectively called the 'exposome'. The skin, as the largest and most exposed organ, can be viewed as a 'window' for the deep exploration of the exposome and its effects on systemic aging. The complex interplay across hallmarks of aging in the skin and systemic biological aging suggests that physiological processes associated with skin aging influence, and are influenced by, systemic hallmarks of aging. This bidirectional relationship provides potential avenues for the prevention of accelerated biological aging and the identification of therapeutic targets. We provide a review of the interactions between skin exposure, aging hallmarks in the skin and associated systemic changes, and their implications in treatment and disease. We also discuss key questions that need to be addressed to maintain skin and overall health, highlighting the need for the development of precise biomarkers and advanced skin models.

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Conflict of interest statement

Competing interests: The following authors are advisors to the Reverse Aging Science Board at Parfums Christian Dior: D.F., J.A., G.C., K.J.A.D., A.D., V.N.G., B.K. K., N.N., D.R., V.S., M.C.W. and K.W. The following authors are employees at Moët Hennessy Louis Vuitton LVMH or Parfums Christian Dior: A.-L.B., V.C., L.C., C.N. and K.P. The other authors declare no competing interests.

References

1. López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M. & Kroemer, G. The hallmarks of aging. Cell 153, 1194–1217 (2013). - PubMed - PMC
1. López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M. & Kroemer, G. Hallmarks of aging: an expanding universe. Cell 186, 243–278 (2023). - PubMed
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Skin health and biological aging

Affiliations

Skin health and biological aging

Authors

Affiliations

Abstract

Conflict of interest statement

References

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Grants and funding

LinkOut - more resources

Full Text Sources

Medical