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Review
. 2025 Jun 17;22(1):61.
doi: 10.1186/s12986-025-00959-4.

Effects of spirulina supplementation on body composition in adults: a GRADE-assessed and dose-response meta-analysis of RCTs

Mohammadyasin Lak  1 , Mehdi Karimi  2 , Camellia Akhgarjand  3 , Shirin Ghotboddin Mohammadi  4 , Pedram Pam  5 , Damoon Ashtary-Larky  6 , Samira Pirzad  7 , Mohammadreza Amirkhan-Dehkordi  8 , Mohammad Amin Shahrbaf  9 , Menno Henselmans  10 , Omid Asbaghi  11
Affiliations
Review

Effects of spirulina supplementation on body composition in adults: a GRADE-assessed and dose-response meta-analysis of RCTs

Mohammadyasin Lak et al. Nutr Metab (Lond). .

Abstract

Background and aim: Weight management remains a global health concern, with increasing interest in nutritional interventions to support healthy body composition. In recent years, the potential role of supplements like Spirulina has gained considerable attention as a possible intervention. This meta-analysis aims to evaluate the effectiveness of Spirulina supplementation on body composition in adults.

Methods: A comprehensive search strategy was conducted across online databases to find relevant RCTs from inception until December 2024. The primary endpoints were changes in anthropometric indices. Meta-analysis and meta-regression were performed using STATA software, and sensitivity, subgroup, and publication bias analyses were also conducted.

Results: The pooled analysis of 17 RCTs indicated that Spirulina supplementation significantly reduced body weight (BW) (WMD: -1.07 kg; p = 0.004), body mass index (BMI) (WMD: -0.40; p = 0.025), body fat percentage (BFP) (WMD: -0.84%; p = 0.002), but had no significant effects on waist circumference (WC) (WMD: -0.46 cm; p = 0.280). Based on Egger's regression test, there is no publication bias for BW (p = 0.097), BMI (p = 0.382), BFP (p = 0.945), and WC (p = 0.488). A significant dose-response effect on BMI and intervention dose (Coefficient: -0.17, P = 0.007) and duration (Coefficient: 0.13, p = 0.042).

Conclusion: Spirulina supplementation effectively reduces BW, BMI, and BFP, with stronger effects at higher doses and longer durations, especially in obese or older individuals. While no significant change in WC was observed overall, subgroup analyses suggest potential benefits for specific populations, emphasizing the importance of personalized supplementation strategies.

Keywords: Anthropometric; Blue-green algae; Body Mass; Dietary Supplement; Nutrition; Spirulina; Weigh.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
PRISMA Flow chart of study selection for inclusion trials in the systematic review
Fig. 2
Fig. 2
Quality assessment of studies according to Cochrane risk-of-bias 2 (RoB-2)
Fig. 3
Fig. 3
Forest plot demonstrating the weighted mean difference (WMD) and 95% confidence intervals (CIs) for the effect of spirulina supplementation on: A) body weight (BW), B) body mass index (BMI) (kg/m2), C) body fat percentage (BF%), D) waist circumference (WC) in adults
Fig. 4
Fig. 4
Funnel plots demonstrating the publication bias for the effect of spirulina supplementation on body weight (BW), body mass index (BMI), Body Fat Percentage (BF%), and waist circumference (WC)
Fig. 5
Fig. 5
Non-linear dose–response relations and absolute mean differences of dose (mg/day) and duration (week) of spirulina supplementation for body weight (BW) and body mass index (BMI)
Fig. 6
Fig. 6
Linear dose–response relations and absolute mean differences of dose (mg/day) and duration (week) of spirulina supplementation for body weight (BW) and body mass index (BMI)
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