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Editorial
. 2025 May 9;16(6):933-934.
doi: 10.1021/acsmedchemlett.5c00246. eCollection 2025 Jun 12.

Novel Isotryptamine Tetracycles as 5‑HT2A Agonists for Treating Brain Disorders

Ram W Sabnis  1
Affiliations
Editorial

Novel Isotryptamine Tetracycles as 5‑HT2A Agonists for Treating Brain Disorders

Ram W Sabnis. ACS Med Chem Lett. .

Abstract

Provided herein are novel isotryptamine tetracycles as 5-HT2A agonists, pharmaceutical compositions, use of such compounds in treating brain disorders, and processes for preparing such compounds.

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References

    1. Schimmelpfennig J., Jankoviak-Siuda K.. Exploring DMT: Endogenous role and therapeutic potential. Neuropharmacology. 2025;268:110314. doi: 10.1016/j.neuropharm.2025.110314. - DOI - PubMed
    1. Gupta, S. ; Bhatnagar, R. K. ; Gupta, D. ; Kumari, M. K. ; Chopra, A. . The evolution of N,N-dimethyltryptamine: from metabolic pathways to brain connectivity. Psychopharmacology 2025, in press. 10.1007/s00213-025-06777-z - DOI - PubMed
    1. Miranda L.. Antidepressant and anxiolytic effects of activating 5-HT2A receptors in the anterior cingulate cortex and the theoretical mechanisms underlying them - A scoping review of available literature. Brain Res. 2025;1846:149226. doi: 10.1016/j.brainres.2024.149226. - DOI - PubMed
    1. Cummins, B. R. ; Billac, G. B. ; Nichols, D. E. ; Nichols, C. D. . 5-HT2A receptors: Pharmacology and functional selectivity. Pharmacol. Rev. 2025, in press. 10.1016/j.pharmr.2025.100059. https://www.sciencedirect.com/science/article/pii/S0031699725074678 - DOI - PubMed
    1. Sabnis R. W.. Novel ergoline compounds as 5-HT2A agonists for treating mood disorders such as depressive disorders and bipolar disorders. ACS Med. Chem. Lett. 2025;16:32–33. doi: 10.1021/acsmedchemlett.4c00593. - DOI - PMC - PubMed

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