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Editorial
. 2025 May 5;16(6):925-926.
doi: 10.1021/acsmedchemlett.5c00229. eCollection 2025 Jun 12.

Novel MALT1 Inhibitors for Treating Cancer

Ram W Sabnis  1
Affiliations
Editorial

Novel MALT1 Inhibitors for Treating Cancer

Ram W Sabnis. ACS Med Chem Lett. .

Abstract

Provided herein are novel MALT1 inhibitors, pharmaceutical compositions, use of such compounds in treating cancer, and processes for preparing such compounds.

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References

    1. Zhang R.-Y., Wang Z.-X., Zhang M.-Y., Wang Y.-F., Zhou S.-L., Xu J.-L., Lin W.-X., Ji T.-R., Chen Y.-D., Lu T., Li N.-G., Shi Z.-H.. MALT1 inhibitors and degraders: Strategies for NF-KB-driven malignancies. J. Med. Chem. 2025;68:5075–5096. doi: 10.1021/acs.jmedchem.4c02873. - DOI - PubMed
    1. Brvar, M. ; O’Neill, T. J. ; Plettenburg, O. ; Karppmann, D. . An updated patent review on MALT1 inhibitors (2021-present). Expert Opin. Ther. Pat. 2025, in press. 10.1080/13543776.2025.2484371. - DOI - PubMed
    1. Yong C., Liang Y., Wang M., Jin W., Fan X., Wang Z., Cao K., Wu T., Li Q., Chang C.. Alternative splicing: A key regulator in T cell response and cancer immunotherapy. Pharmacol. Res. 2025;215:107713. doi: 10.1016/j.phrs.2025.107713. - DOI - PubMed
    1. Sabnis R. W.. MALT1 inhibitors for treating cancer and immunological diseases. ACS Med. Chem. Lett. 2024;15:1419–1420. doi: 10.1021/acsmedchemlett.4c00390. - DOI - PMC - PubMed
    1. O’Neill T. J., Tofaute M. J., Karppmann D.. Function and targeting of MALT1 paracaspase in cancer. Cancer Treat. Rev. 2023;117:102568. doi: 10.1016/j.ctrv.2023.102568. - DOI - PubMed

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