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. 2025 Jun 2:16:1533853.
doi: 10.3389/fneur.2025.1533853. eCollection 2025.

A study on resting-state functional near-infrared spectroscopy in patients with different outcomes of prolonged disorders of consciousness

Yanli Liang #  1 , Xin Liang #  2 , Yijiang Li  3 , Chaowen Wang  4 , Yinuo Bi  4 , Yuan Xue  4 , Wenyu Jiang  1
Affiliations

A study on resting-state functional near-infrared spectroscopy in patients with different outcomes of prolonged disorders of consciousness

Yanli Liang et al. Front Neurol. .

Erratum in

Abstract

Background: To explore the characteristics of resting-state functional connectivity in patients with different outcomes of prolonged disorders of consciousness (pDoC) by studying resting-state near-infrared imaging in patients with pDoC.

Methods: 60 patients with pDoC were processed with resting-state near-infrared imaging and divided into unresponsive wakefulness syndrome/vegetative state (UWS/VS) group, minimally conscious state (MCS) group and escape minimally conscious state (EMCS) group according to the post-treatment state of consciousness, to analyze the difference of resting-state functional connectivity in patients with different outcomes of patients with pDoC.

Results: Functional connectivity (FC) between frontal lobe and left occipital lobe, frontal lobe and right occipital lobe, and left and right occipital lobes decreased in the UWS/VS group compared with the MCS group; functional connectivity between frontal lobe and left occipital lobe, frontal lobe and right occipital lobe, and left and right occipital lobes decreased in the UWS/VS group compared with the EMCS group; functional connectivity did not show any significant difference between the EMCS and MCS groups; and functional connectivity was more centralized in the MCS group and EMCS group.

Conclusion: Different outcomes of patients with pDoC have different degrees of decline in functional connectivity between frontal lobe and occipital lobe and between occipital lobe, resting-state functional near-infrared spectroscopy has a certain reference significance for the prognosis of patients with pDoC, and it is helpful for exploring the exploration of the conscious residual brain areas.

Keywords: functional connectivity; functional near-infrared spectroscopy; outcomes; prolonged disorders of consciousness; resting-state.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor DW declared a past co-authorship with the author WJ.

Figures

Figure 1
Figure 1
Functional near infrared acquisition device.
Figure 2
Figure 2
Channel arrangement of fNIRS brain functional imaging device. (A) The purple (S) and blue circles (D) represent the light source and the detector respectively, while the connecting lines between them represent the channels. (B) The layout diagram of 19 channels on the frontal lobe. (C) The layout diagram of 8 channels on the occipital lobe.
Figure 3
Figure 3
Functional connection of each channel in UWS/VS group. Connectivity matrix of 27 channels in UWS/VS group.
Figure 4
Figure 4
Functional connection of each channel in MCS group. Connectivity matrix of 27 channels in MCS group.
Figure 5
Figure 5
Functional connection of each channel in EMCS group. Connectivity matrix of 27 channels in EMCS group.
Figure 6
Figure 6
Three groups of average functional connection strength distribution. (A) Average functional connection strength distribution in UWS/VS group. (B) Average functional connection strength distribution in MCS group. (C) Average functional connection strength distribution in EMCS group. (D) Average functional connection strength distribution in three groups.
See this image and copyright information in PMC

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