Does circulating DNA tumor fraction add value to prostate-specific antigen in metastatic castration-resistant prostate cancer?
- PMID: 40530150
- PMCID: PMC12170075
- DOI: 10.21037/tcr-2025-295
Does circulating DNA tumor fraction add value to prostate-specific antigen in metastatic castration-resistant prostate cancer?
Keywords: Circulating tumor DNA (ctDNA); metastatic castration-resistant prostate cancer (mCRPC); tumor fraction (TF).
Conflict of interest statement
Conflicts of Interest: Both authors have completed the ICMJE uniform disclosure form (available at https://tcr.amegroups.com/article/view/10.21037/tcr-2025-295/coif). C.N.S. has received funds from Astellas Pharma, AstraZeneca, Bayer, Bristol-Myers Squibb/Medarex, Foundation Medicine, Genzyme, Gilead, Merck, MSD, Pfizer, Janssen, Roche, Medscape, UroToday, and Tolmar. M.H. has received funds from Bayer, Convergent, Astra Zeneca, MJH, RTP, PER, BMS and is a trustee, member of Board of Prostate Cancer, UK and member of Steering Committee, MOVEMBER Global Collaborative Program in Disease Progression. The authors have no other conflicts of interest to declare.
Comment on
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Circulating Tumor DNA Assessment for Treatment Monitoring Adds Value to PSA in Metastatic Castration-Resistant Prostate Cancer.Clin Cancer Res. 2024 Sep 13;30(18):4115-4122. doi: 10.1158/1078-0432.CCR-24-1096. Clin Cancer Res. 2024. PMID: 38990098 Free PMC article. Clinical Trial.
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