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Review
. 2025 Jun 18.
doi: 10.1007/s10787-025-01812-z. Online ahead of print.

The therapeutic potential of naturally occurring 6-shogaol: an updated comprehensive review

Kareem A Attallah  1   2 , Ahmed M El-Dessouki  3 , Mai A Abd-Elmawla  4 , Heba R Ghaiad  4 , Fatma Abo-Elghiet  5 , Aya M Mustafa  6 , Riham A El-Shiekh  7 , Heba Elosaily  8
Affiliations
Review

The therapeutic potential of naturally occurring 6-shogaol: an updated comprehensive review

Kareem A Attallah et al. Inflammopharmacology. .

Abstract

Shogaol, a significant bioactive constituent of ginger, is present in several forms, including 4-, 6-, 8-, 10-, and 12-shogaol, with 6-shogaol identified as the most potent among them. Notably, 6-shogaol can be metabolized into 6-paradol, a compound that lacks pungency but retains biological activity. The primary focus of this review is to trace the diverse pharmacological effects of 6-shogaol, such as its anti-inflammatory, cardioprotective, neuroprotective, antioxidant, and anticancer properties, and to document the molecular mechanisms underlying these actions. 6-Shogaol's broad spectrum of benefits makes it valuable in the health, food, and beverage industries, where its unique taste, high biocompatibility, and ability to alleviate or prevent various health issues are particularly advantageous. Its multiple mechanisms of action, including the modulation of oxidative stress and inflammation, contribute to its reputation as a promising natural compound. By highlighting the therapeutic potential of 6-shogaol, this review aims to provide a scientific foundation for its future development, clinical application, and incorporation into functional foods or pharmaceuticals, ultimately supporting its role as a versatile agent in promoting human health.

Keywords: 6-Shogaol; Functional foods; Ginger; Health benefits; Nutraceuticals.

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Conflict of interest statement

Declarations. Competing interest: The authors have not disclosed any competing interests.

References

    1. Abd-Elmawla MA et al (2024) The interplay of TapSAKI and NEAT-1 as potential modulators in gentamicin-induced acute kidney injury via orchestrating miR-22-3p/TLR4/MyD88/NF-қB/IL-1 β milieu: novel therapeutic approach of Betanin. Intern Immunopharm 143:113577 - DOI
    1. Afzal M et al (2021) 6-Shogaol attenuated ethylene glycol and aluminium chloride induced urolithiasis and renal injuries in rodents. Saudi J Biol Sci 28(6):3418–3423 - PubMed - PMC - DOI
    1. Afzal M et al (2021) 6-Shogaol attenuates traumatic brain injury-induced anxiety/depression-like behavior via inhibition of oxidative stress-influenced expressions of inflammatory mediators TNF-α, IL-1β, and BDNF: insight into the mechanism. ACS Omega 7(1):140–148 - PubMed - PMC - DOI
    1. Ajeigbe OF et al (2022) 6-shogaol suppresses AOM/DSS-mediated colorectal adenoma through its antioxidant and anti-inflammatory effects in mice. J Food Biochem 46(12):e14422 - PubMed - DOI
    1. Akimoto M et al (2015) Anticancer effect of ginger extract against pancreatic cancer cells mainly through reactive oxygen species-mediated autotic cell death. PloS One 10(5):e0126605 - PubMed - PMC - DOI