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Review
. 2025 Sep;263(9):2475-2483.
doi: 10.1007/s00417-025-06869-8. Epub 2025 Jun 18.

Connecting the dots: the role of genetics in posterior vitreous detachment

Rajya L Gurung  1 , Stewart Lake  2 , Shane Durkin  3   4 , David Sia  3   2 , Jagjit Gilhotra  3   4 , Weng Onn Chan  3   4
Affiliations
Review

Connecting the dots: the role of genetics in posterior vitreous detachment

Rajya L Gurung et al. Graefes Arch Clin Exp Ophthalmol. 2025 Sep.

Abstract

The vitreous is a transparent homogenous gel comprised predominantly of water. It is firmly attached to the internal limiting membrane in young healthy individuals. As part of the physiological aging process, the separation of the posterior vitreous cortex from the internal limiting membrane is called physiological posterior vitreous detachment (PVD), which usually occurs without ocular complications. On the contrary, anomalous PVD can have various sight-threatening complications. The cause of this difference is poorly understood and is a topic of future research. Further, newer evidence indicates that anomalous PVD may be genetically influenced.

Keywords: Anomalous posterior vitreous detachment; Genetics; Pathogenesis; Vitreous.

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Conflict of interest statement

Declarations. Ethical approval: This manuscript does not contain any studies with human participants performed by any of the authors. Conflict of interest: All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript.

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