Chromatographic-based 103Ru/103mRh generator for Auger therapy

Abstract

Conversion and Auger electrons are promising for vectorized internal radiotherapy for cancer treatment, in addition to α and β^- particles. Rhodium-103 m (t_1/2 = 56.11 min) is an interesting candidate for Auger Therapy and can be produced from Ruthenium-103. The development of a ¹⁰³Ru/^103mRh generator would provide the possibility of regular supply of ^103mRh to evaluate its therapeutic potential. In this study, chromatographic separation system allowing Ru retention and Rh elution in chlorinated environment was investigated. A resin based on trioctylphosphine oxide functional groups (TK200) showed promising results. Results with dynamic separations revealed high Rh elution. In addition, Ru partial elution was visible and estimated to 4-8 % of initial amount of Ru. The hypothesis that Ru partial elution was due to Ru(III) presence, not retained by TK200 resin, was suggested and verified. Generator concept has also been tested with ⁹⁷⁺¹⁰³Ru radioactive isotopes. A reduction in Ru partial elution was observed compared to results obtained with stable Ru isotopes. ¹⁰³Ru/¹⁰³ᵐRh generator developed in this study is operational, even if further improvements are necessary.

Keywords: Auger therapy; Chromatographic resin-based separation; Rhodium; Ruthenium.