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. 2025 Aug;78(9):552-559.
doi: 10.1038/s41429-025-00841-8. Epub 2025 Jun 18.

Study about fluostatins: efficient preparation of fluostatin A and discovery of fluostatin derivatives from Streptomyces sp. TA-3391

Shigehiro Tohyama  1 , Seiji Nukui  2 , Masaki Hatano  3 , Chigusa Hayashi  3 , Isao Momose  4 , Masayuki Igarashi  3
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Study about fluostatins: efficient preparation of fluostatin A and discovery of fluostatin derivatives from Streptomyces sp. TA-3391

Shigehiro Tohyama et al. J Antibiot (Tokyo). 2025 Aug.

Abstract

Fluostatins are a class of compounds having four unique ring systems. They were originally isolated as dipeptidyl peptidase III (DPP3) inhibitors, and various derivatives and activities have been reported. In this study, fluostatin A, which is difficult to prepare by fermentative production, was effectively prepared by the transformation of fluostatin B. A new derivative, fluostatin Y, and a new naturally occurring derivative, fluostatin B2, were obtained, and their structures were determined. Furthermore, the bioactivity, DPP3 inhibitory activity, and antibacterial and cytotoxic activities were examined.

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Conflict of interest statement

Compliance with ethical standards. Conflict of interest: The authors declare no competing interests.

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