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Review
. 2025 Jun 18;52(1):613.
doi: 10.1007/s11033-025-10638-5.

Circular RNA rising star: new findings of circPRMT5 in cancer

DuanZhong Chen  1   2 , CaiYan Yin  1   2 , Chao Li  1 , Jun He  3 , Peng Wu  4   5
Affiliations
Review

Circular RNA rising star: new findings of circPRMT5 in cancer

DuanZhong Chen et al. Mol Biol Rep. .

Abstract

Circular RNA (circRNA), a type of noncoding RNA, features a covalently closed circular structure lacking 5'-3' polarity and a polyadenylated tail. Its resistance to RNase R degradation endows it with greater stability and resilience than linear RNA, leading to a prolonged half-life. Recent research has highlighted the crucial role of circRNAs, especially circPRMT5, in diverse cancers. CircPRMT5 is generated by reverse splicing of exon 18 within a 682-nucleotide gene. In various cancer cells, elevated circPRMT5 expression is correlated with increased tumor cell proliferation, migration, and invasion abilities. It impacts tumor progression by regulating cell proliferation, migration, invasion, and chemotherapy resistance. This review comprehensively examines the expression patterns, mechanisms, and clinical potential of circPRMT5 in cancers such as breast, bladder, nonsmall cell lung, esophageal, thyroid, liver, colorectal, and gastric cancer. Overall, circPRMT5 shows promise as a biomarker and therapeutic target, providing valuable insights for future cancer research and treatment strategies.

Keywords: Cancer; CircPRMT5; Circular RNA; Drug resistance; Mechanisms; Therapy.

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Conflict of interest statement

Declarations. Conflict of interest: The authors declare no competing interests. Ethical approval: This article does not contain any studies with human participants or animals performed by any of the authors.

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