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Review
. 2025 Jun 4:7:1622123.
doi: 10.3389/fdgth.2025.1622123. eCollection 2025.

Emerging technologies transforming the future of global biosecurity

Renan Chaves de Lima  1   2 , Juarez Antonio Simões Quaresma  3
Affiliations
Review

Emerging technologies transforming the future of global biosecurity

Renan Chaves de Lima et al. Front Digit Health. .

Abstract

The convergence of artificial intelligence and synthetic biology offers transformative opportunities to enhance global biosecurity. Emerging technologies promise rapid detection, containment, and mitigation of global biological threats, while simultaneously raising complex ethical and security challenges. This research aims to critically examine advances in AI applications for biosecurity, innovations in vaccine development enabled by synthetic biology, and the risks associated with the democratization of powerful biotechnological tools. We highlight both the potential and the dangers of integrating these technologies into public health preparedness systems and advocate for the establishment of robust governance frameworks to ensure their ethical and equitable implementation.

Keywords: artificial intelligence; biosecurity; emerging technologies; global preparedness; public health; synthetic biology.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.

Figures

Figure 1
Figure 1
Global biosecurity preparedness through AI and synthetic biology. Description: The figure illustrates the strategic convergence of emerging technologies such as artificial intelligence and synthetic biology to strengthen global biosecurity. The main pillars include threat detection, real-time surveillance, rapid vaccine development, and gene editing for personalized therapies.
See this image and copyright information in PMC

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References

    1. Morens DM, Fauci AS. Emerging pandemic diseases: how we got to COVID-19. Cell. (2020) 182:1077–92. 10.1016/j.cell.2020.08.021 - DOI - PMC - PubMed
    1. Holmes EC, Goldstein SA, Rasmussen AL, Robertson DL, Crits-Christoph A, Wertheim JO, et al. The origins of SARS-CoV-2: a critical review. Cell. (2021) 184:4848–56. 10.1016/j.cell.2021.08.017 - DOI - PMC - PubMed
    1. Sandbrink JB. Artificial intelligence and biological misuse: differentiating risks of language models and biological design tools. arXiv [preprint]. arXiv:2306.13952. (2023):1–9. 10.48550/arXiv.2306.13952 - DOI
    1. Militzer N, McLaws M, Rozstalnyy A, Li Y, Dhingra M, Auplish A, et al. Characterising biosecurity initiatives globally to support the development of a progressive management pathway for terrestrial animals: a scoping review. Animals (Basel). (2023) 13(16):2672. 10.3390/ani13162672 - DOI - PMC - PubMed
    1. Vickers CE, Freemont PS. Pandemic preparedness: synthetic biology and publicly funded biofoundries can rapidly accelerate response time. Nat Commun. (2022) 13:453. 10.1038/s41467-022-28103-3 - DOI - PMC - PubMed

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