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. 2025 Jun 4:16:1562493.
doi: 10.3389/fendo.2025.1562493. eCollection 2025.

Percutaneous ethanol and calcitriol injection therapy for hyperparathyroidism - a single-centre experience

Eugene Kwong Fei Leong  1   2 , Ray Meng See  2 , Zhimin Lin  1   3 , Meredeth Choon Siang Chin  2 , Joshua Wei Yang Chew  1 , Kee Yuan Ngiam  1 , James Wai Kit Lee  1   2   4
Affiliations

Percutaneous ethanol and calcitriol injection therapy for hyperparathyroidism - a single-centre experience

Eugene Kwong Fei Leong et al. Front Endocrinol (Lausanne). .

Abstract

Background: The purpose of this study is to evaluate the use of percutaneous ethanol and calcitriol injection therapy for hyperparathyroidism (HPT), while taking into account the efficacy, safety and feasibility as an ambulatory procedure alternative to surgical parathyroidectomy.

Methods: We included nine patients who underwent percutaneous injection therapy for HPT from January 2018 to December 2021 in our institution. They were followed up from date of first percutaneous injection until death or October 2022 (mean duration of 9.0 months).

Results: Four patients underwent percutaneous ethanol injection therapy (PEIT) (mean age 61.0 [31-89] years old), while the remaining five underwent percutaneous calcitriol therapy (PCIT) (mean age 62.6 [35-91] years old). The analyzed parameters are age, BMI, serum turn over markers as iPTH, Ca, alkaline phosphatase and vitamin D. Two out of the four patients undergoing PEIT had a successful outcome, although one needed to continue cinacalcet due to persistent serum calcium levels. Three out of five PCIT patients in our series had successful procedure, although one subsequently developed refractory disease.

Conclusion: PEIT and PCIT are feasible and safe therapeutic alternatives to surgical parathyroidectomy in HPT refractory to medical treatment, with postulated benefits of decreased costs and being an outpatient procedure. However, further studies are necessary to evaluate the efficacy and cost-effectiveness with these techniques prior to widespread adoption.

Keywords: calcium; case series; hyperparathyroidism; parathyroid adenoma; percutaneous injection.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Serum iPTH in patients undergoing PEIT.
Figure 2
Figure 2
Serum calcium in patients undergoing PEIT.
Figure 3
Figure 3
Serum iPTH in patients undergoing PCIT.
Figure 4
Figure 4
Serum calcium in patients undergoing PCIT.
See this image and copyright information in PMC

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