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. 2025;317(1):812.
doi: 10.1007/s00403-025-04303-x. Epub 2025 Jun 16.

The role of selected cytokines from the interleukin 1 family in the pathophysiology of morphea

Paulina Cieplewicz-Guźla  1 , Michał J Kowalczyk  1 , Aleksandra Dańczak-Pazdrowska  1 , Ryszard Żaba  1 , Joanna Wegner  2 , Adriana Polańska  1
Affiliations

The role of selected cytokines from the interleukin 1 family in the pathophysiology of morphea

Paulina Cieplewicz-Guźla et al. Arch Dermatol Res. 2025.

Abstract

Morphea (localized scleroderma) is a chronic, autoimmune disease of connective tissue that has been known for many years. However, the etiology of the disease is still not fully understood. The study was conducted on a group of 88 people, including 59 patients with morphea and 29 people qualified for the control group. We attempted to assess gene expression and plasma concentration IL-1β, IL-18 and IL-33. In the group of patients with morphea, a lower expression of IL1 beta and IL18 genes was observed in PBMC compared to the control group, and no significant differences in plasma concentrations of IL-1β, IL-18 and IL-33 were found in the group of patients with morphea compared to the control group.

Keywords: Interleukin 18; Interleukin 1β; Interleukin 33; Morphea; Scleroderma.

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Conflict of interest statement

Conflict of interestThe authors have no conflicts of interest to declare.

Figures

Fig. 1
Fig. 1
Assessment of the correlation between IL18 gene expression in PBMC and PGA-A
Fig. 2
Fig. 2
Assessment of the correlation between plasma IL-18 concentration and PGA-D
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