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. 2025 May 15;17(5):3665-3673.
doi: 10.62347/RKJN6285. eCollection 2025.

Transurethral holmium laser enucleation of prostate shows remarkable efficacy in treating benign prostatic hyperplasia

Feng-Rong He  1 , Guo-Deng Jian  1 , Ri-Zhao Tan  1 , Yi-Nuo Xu  1 , Bin Zheng  1
Affiliations

Transurethral holmium laser enucleation of prostate shows remarkable efficacy in treating benign prostatic hyperplasia

Feng-Rong He et al. Am J Transl Res. .

Abstract

Objective: To evaluate the effects of transurethral holmium laser enucleation of the prostate (HoLEP) in treating benign prostatic hyperplasia (BPH).

Methods: This retrospective study included 100 BPH patients who visited Foshan Fosun Chancheng Hospital from January 2022 to June 2023. Patients were divided into two groups: 50 treated with transurethral resection of the prostate (control group) and 50 with transurethral HoLEP (observation group). We compared clinical efficacy, surgical parameters, maximum urinary flow rate (Qmax), post-void residual volume (PRV), prostate-specific antigen (PSA), hemoglobin (Hb), interleukin-6 (IL-6), C-reactive protein (CRP), International Prostate Symptom Score (IPSS), quality of life (QOL), and complication rates.

Results: The observation group showed significantly reduced operative time, blood loss, catheterization duration, and hospitalization compared to the control group (all P<0.05). Postoperatively, Qmax was higher and PRV lower in the observation group (both P<0.05). PSA was lower, and Hb was higher in the observation group than those in the control group (both P<0.05). Both IL-6 and CRP levels increased post-surgery, but were significantly lower in the observation group (both P<0.05). The observation group also had better IPSS and QOL scores and a lower complication rate (16% vs. 56%, all P<0.05).

Conclusion: HoLEP is an effective treatment for BPH, offering advantages such as reduced surgical time, lower complication rates, improved urodynamics, and better patient outcomes in terms of symptoms and quality of life.

Keywords: Holmium laser enucleation of the prostate; benign prostatic hyperplasia; efficacy; transurethral resection of the prostate.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Comparison of serum inflammatory factors before and after surgery. A. Pre- and post-operative IL-6 levels in the two groups. B. Pre- and post-operative CRP levels in the two groups. Note: IL-6, interleukin-6; CRP, C-reactive protein. *P<0.05 vs. the level before surgery; #P<0.05 vs. the control group.
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