Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 May 15;17(5):3454-3464.
doi: 10.62347/RKQX9577. eCollection 2025.

A comparison of three whitening protocols for mild-to-moderate dental fluorosis in anterior teeth

Affiliations

A comparison of three whitening protocols for mild-to-moderate dental fluorosis in anterior teeth

Meixi Zhou et al. Am J Transl Res. .

Abstract

Objective: This research compares the effectiveness of three whitening treatments for mild-to-moderate dental fluorosis in the front teeth.

Method: This retrospective study analysis is based on 51 mild-to-moderate dental fluorosis cases. The patients who visited the Dental Hospital of Ningxia Medical University from August 2020 to August 2021 were enrolled as research cases. The patients were classified into three groups according to their treatment plans: Group A (19 cases), Group B (17 cases), and Group C (15 cases). The upper anterior teeth color was assessed immediately after treatment and then at one week, one month, three months, and six months using the VITA Easyshade® V shade guide. Tooth sensitivity was evaluated with a visual analog scale (VAS scale).

Results: Three options were applied to treat mild and moderate dental fluorosis. Moderate fluorosis showed higher ΔE and ΔL values but lower Δa and Δb values compared to mild fluorosis, with significant differences noted (P<0.05). In cases of mild dental fluorosis, ΔE and ΔL values from the combination of micro-grinding and home bleaching were significantly higher. Conversely, Δa and Δb values for both micro-grinding with home bleaching and micro-grinding with combined bleaching were significantly lower (P<0.05). In moderate dental fluorosis cases, ΔE and ΔL values were higher for both micro-grinding combined with bleaching and micro-grinding combined with home bleaching. In contrast, Δa and Δb values for micro-grinding combined with bleaching were lower, showing statistically significant differences (P<0.05). The sensitivity of micro-grinding + home bleaching was less than that of micro-grinding + in-office bleaching and micro-grinding + combined bleaching immediately post-op, 1 week after the operation, with statistically significant differences (P<0.05).

Conclusion: All three options achieve sound whitening effects for mild to moderate dental fluorosis in anterior teeth. The whitening effect is more effective in cases of moderate dental fluorosis than in mild cases. Among the three treatment options, microabrasion combined with home bleaching achieves the best whitening effect for mild dental fluorosis and minimizes sensitivity. When considering the three treatment options for moderate dental fluorosis, both microabrasion combined with home bleaching and microabrasion combined with in-office bleaching can yield better whitening effects. However, it is essential to note that the latter option is linked to higher sensitivity.

Keywords: Dental fluorosis; combined bleaching; home bleaching; in-office bleaching; microabrasion; sensitivity.

PubMed Disclaimer

Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Comparison of ΔE values at different postoperative time points for different treatment methods, tooth types, and dental fluorosis severity. Note: A: Comparison of ∆E values for different postoperative treatment; B: Comparison of ∆E values between different teeth after treatment; C: Comparison of ∆E values between different severities of postoperative Fluorosis.
Figure 2
Figure 2
The changes in ΔL (A, B), Δa (C, D), Δb (E, F), and ΔE (G, H) at 5 evaluation time points for the three treatment schemes in mild and moderate dental fluorosis. Note: A’: Micro-polishing + In-Office Whitening. B’: Micro-polishing + Home Whitening. C’: Micro-polishing + Combined Whitening. (A) ΔL of mild dental fluorosis. (B) ΔL of moderate dental fluorosis. (C) Δa of mild dental fluorosis. (D) Δa of moderate dental fluorosis. (E) Δb of mild dental fluorosis. (F) Δb of moderate dental fluorosis. (G) ΔE of mild dental fluorosis. (H) ΔE of moderate dental fluorosis.
Figure 3
Figure 3
Comparison of tooth sensitivity at five time points after light and moderate dental fluorosis treatment with three whitening protocols. Note: imm, 1W, 1M, 3M, 6M refer to immediately postoperatively, 1 week, 1 month, 3 months, and 6 months postoperatively, respectively. VAS refers to the median VAS value of patients at different time points after treatment. A: VAS of moderate fluorosis; B: VAS of mild fluorosis.

Similar articles

References

    1. Gu LS, Wei X, Ling JQ. Etiology, diagnosis, prevention and treatment of dental fluorosis. Zhonghua Kou Qiang Yi Xue Za Zhi. 2020;55:296–301. - PubMed
    1. Wang Q, Meng Q, Meng J. Minimally invasive esthetic management of dental fluorosis: a case report. J Int Med Res. 2020;48:300060520967538. - PMC - PubMed
    1. Alshammari FR, Aljohani M, Botev L, O’malley L, Glenny AM. Dental fluorosis prevalence in Saudi Arabia. Saudi Dent J. 2021;33:404–412. - PMC - PubMed
    1. Zotti F, Albertini L, Tomizioli N, Capocasale G, Albanese M. Resin infiltration in dental fluorosis treatment-1-year follow-up. Medicina (Kaunas) 2020;57:22. - PMC - PubMed
    1. Hung M, Hon ES, Mohajeri A, Moparthi H, Vu T, Jeon J, Lipsky MS. A national study exploring the association between fluoride levels and dental fluorosis. JAMA Netw Open. 2023;6:e2318406. - PMC - PubMed

LinkOut - more resources