Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2025 Apr 27:61:21-25.
doi: 10.1016/j.jdcr.2025.04.014. eCollection 2025 Jul.

A rare presentation of the diffuse dermal mucinosis in adenocarcinoma of the lungs treated with pembrolizumab and pemetrexed

Karen Koch  1   2 , Kamal Solanki  1   2   3 , Julia Zhu  1
Affiliations
Case Reports

A rare presentation of the diffuse dermal mucinosis in adenocarcinoma of the lungs treated with pembrolizumab and pemetrexed

Karen Koch et al. JAAD Case Rep. .
No abstract available

Keywords: drug-related mucinosis; generalized mucinosis; mucinosis; paraneoplastic mucinosis; pembrolizumab; pemetrexed; scleredema.

PubMed Disclaimer

Conflict of interest statement

Dr Solanki is an Honorary Adjunct Professor of Apollo Hospitals Educational and Research Foundation (AHERF), India. Drs Koch and Zhu have no conflicts of interest to declare.

Figures

Fig 1
Fig 1
Photos showing the swelling of face and hands. A, Swelling of the dorsum aspect of the hands. B, Swelling of the palmar aspect of the hands. C, Swelling of the face.
Fig 2
Fig 2
A, Skin biopsy with hematoxylin-eosin stain, demonstrating normal epidermis. B, C, Skin biopsy with Alcian blue and periodic acid–Schiff stains. The increased blue material between the collagen bundles is mucin (see arrow). (A, Hematoxylin-eosin stain; B, Alcian blue stain; C, periodic acid–Schiff stain; original magnifications: A, ×100; B, ×20; C, ×200.)
Fig 3
Fig 3
Magnetic resonance imaging of the right hand during treatment (T2 coronal view): yellow arrow pointing to the subcutaneous mucinosis.
Fig 4
Fig 4
Magnetic resonance imaging of the right hand 8 months after completing chemotherapy showing reduction in dermal mucin (yellow arrow).
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Rongioletti F. New and emerging conditions of acquired cutaneous mucinoses in adults. J Eur Acad Dermatol Venereol. 2022;36(7):1016–1024. doi: 10.1111/jdv.17983. - DOI - PubMed
    1. Nakatsuji M., Ishimaru N., Ohnishi J., et al. Scleredema with biopsy-confirmed cardiomyopathy: a case report. J Scleroderma Relat Disord. 2021;6(3):311–315. doi: 10.1177/23971983211013977. - DOI - PMC - PubMed
    1. Rongioletti F., Kaiser F., Cinotti E., et al. Scleredema. A multicentre study of characteristics, comorbidities, course and therapy in 44 patients. J Eur Acad Dermatol Venereol. 2015;29(12):2399–2404. doi: 10.1111/jdv.13272. - DOI - PubMed
    1. Patel D.R., Vora N., Chaudhary R., Sharma V., Dadhaniya N.V. Scleredema adultorum of buschke associated with diffuse eosinophilia and hepatitis B virus infection. Cureus. 2023;15(4) doi: 10.7759/cureus.38300. - DOI - PMC - PubMed
    1. Rongioletti F., Rebora A. Updated classification of papular mucinosis, lichen myxedematosus, and scleromyxedema. J Am Acad Dermatol. 2001;44(2):273–281. doi: 10.1067/mjd.2001.111630. - DOI - PubMed

Publication types

LinkOut - more resources