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Case Reports
. 2025 Jun 4:19:1570726.
doi: 10.3389/fnins.2025.1570726. eCollection 2025.

Mixed drug overdose involving clonazepam, alprazolam, and olanzapine in a 72-year-old male with Parkinson's disease: a case report

Wei Zhang  1 , Mao-Shui Wang  2 , Jianguo Zhang  3 , Chunhai Gao  4
Affiliations
Case Reports

Mixed drug overdose involving clonazepam, alprazolam, and olanzapine in a 72-year-old male with Parkinson's disease: a case report

Wei Zhang et al. Front Neurosci. .

Abstract

This case report discusses a 72-year-old male patient with Parkinson's disease, depression, and somatization disorder, presenting to the emergency department after a suspected overdose of clonazepam. The patient was discovered unconscious approximately 2.5 h after ingestion of over 30 tablets of clonazepam, in combination with an overdose of alprazolam and olanzapine. Despite initial challenges with gastric lavage, subsequent treatment involved supportive care, management of complications such as pneumonia, and renal replacement therapy, ultimately leading to recovery. This case highlights the complexities of managing overdoses, particularly those involving drugs with long half-lives, and highlights the challenges of treating elderly patients and the importance of supportive care in recovery.

Keywords: clonazepam; elderly patient; overdose; pneumonia; renal replacement therapy.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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