Comment on

• Beyond genotype: challenges in predicting disease risk for carriers of biallelic perforin variants.

  Wegehaupt O, Borisov O, Sieni E, Oyen F, Mann J, Coniglio ML, Chinnici A, Pegoraro F, Beneforti L, Gilmour K, Moshous D, de Saint Basile G, Zhang W, Marsh R, De Fusco C, Wustrau K, Timeus F, Micalizzi C, Gunsilius E, Hosking L, Choo S, Ghosh S, Köttgen A, Lehmberg K, Ehl S. Wegehaupt O, et al. Blood. 2025 Jun 19;145(25):2992-3006. doi: 10.1182/blood.2024027954. Blood. 2025. PMID: 40090000