Achilles' Heel of Aortic Aneurysms: Adipose-Myofibroblast Differentiation

doi:10.1161/CIRCRESAHA.125.326726

Editorial

. 2025 Jun 20;137(1):23-25.

doi: 10.1161/CIRCRESAHA.125.326726. Epub 2025 Jun 19.

Achilles' Heel of Aortic Aneurysms: Adipose-Myofibroblast Differentiation

Muhammad Yogi Pratama^{1

2}, Bhama Ramkhelawon^{1

2}

Affiliations

¹ Division of Vascular and Endovascular Surgery, Department of Surgery (M.Y.P., B.R.), New York University Langone Medical Center.
² Department of Cell Biology (M.Y.P., B.R.), New York University Langone Medical Center.

PMID: 40536941
PMCID: PMC12208653 (available on 2026-06-20)
DOI: 10.1161/CIRCRESAHA.125.326726

Editorial

Achilles' Heel of Aortic Aneurysms: Adipose-Myofibroblast Differentiation

Muhammad Yogi Pratama et al. Circ Res. 2025.

. 2025 Jun 20;137(1):23-25.

doi: 10.1161/CIRCRESAHA.125.326726. Epub 2025 Jun 19.

Authors

Muhammad Yogi Pratama^{1

2}, Bhama Ramkhelawon^{1

2}

Affiliations

¹ Division of Vascular and Endovascular Surgery, Department of Surgery (M.Y.P., B.R.), New York University Langone Medical Center.
² Department of Cell Biology (M.Y.P., B.R.), New York University Langone Medical Center.

PMID: 40536941
PMCID: PMC12208653 (available on 2026-06-20)
DOI: 10.1161/CIRCRESAHA.125.326726

No abstract available

Keywords: Editorials; aortic aneurysm; cell differentiation; myofibroblasts; vascular smooth muscle.

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Conflict of interest statement

None.

Comment on

SM22α-Lineage Perivascular Stromal Cells Contribute to Abdominal Aortic Aneurysm.
Pan X, Zhang R, Lu B, Chen S, Chen H, Li M, Qin L, Song Z, Yang Y, Wang Z, Yan F, Sun A, Wu F, Zhang L, Wang J, Guzik TJ, Gao P. Pan X, et al. Circ Res. 2025 Jun 20;137(1):4-22. doi: 10.1161/CIRCRESAHA.124.325750. Epub 2025 May 15. Circ Res. 2025. PMID: 40371535

References

1. Chakraborty A, Li Y, Zhang C, Li Y, Rebello KR, Li S, Xu S, Vasquez HG, Zhang L, Luo W, et al. Epigenetic Induction of Smooth Muscle Cell Phenotypic Alterations in Aortic Aneurysms and Dissections. Circulation. 2023;148:959–977. doi: 10.1161/CIRCULATIONAHA.123.063332 - DOI - PMC - PubMed
1. Dobnikar L, Taylor AL, Chappell J, Oldach P, Harman JL, Oerton E, Dzierzak E, Bennett MR, Spivakov M, Jorgensen HF. Disease-relevant transcriptional signatures identified in individual smooth muscle cells from healthy mouse vessels. Nat Commun. 2018;9:4567. doi: 10.1038/s41467-018-06891-x - DOI - PMC - PubMed
1. Pan X, Zhang R, Lu B, Chen S, Chen H, Li M, Qin L, Song Z, Yang Y, Wang Z, et al. SM22alpha-Lineage Perivascular Stromal Cells Contribute to Abdominal Aortic Aneurysm. Circ Res. 2025. doi: 10.1161/CIRCRESAHA.124.325750 - DOI - PubMed
1. Golledge J Abdominal aortic aneurysm: update on pathogenesis and medical treatments. Nat Rev Cardiol. 2019;16:225–242. doi: 10.1038/s41569-018-0114-9 - DOI - PubMed
1. Qian W, Hadi T, Silvestro M, Ma X, Rivera CF, Bajpai A, Li R, Zhang Z, Qu H, Tellaoui RS, et al. Microskeletal stiffness promotes aortic aneurysm by sustaining pathological vascular smooth muscle cell mechanosensation via Piezo1. Nat Commun. 2022;13:512. doi: 10.1038/s41467-021-27874-5 - DOI - PMC - PubMed

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[1] Chakraborty A, Li Y, Zhang C, Li Y, Rebello KR, Li S, Xu S, Vasquez HG, Zhang L, Luo W, et al. Epigenetic Induction of Smooth Muscle Cell Phenotypic Alterations in Aortic Aneurysms and Dissections. Circulation. 2023;148:959–977. doi: 10.1161/CIRCULATIONAHA.123.063332 - DOI - PMC - PubMed

[2] Chakraborty A, Li Y, Zhang C, Li Y, Rebello KR, Li S, Xu S, Vasquez HG, Zhang L, Luo W, et al. Epigenetic Induction of Smooth Muscle Cell Phenotypic Alterations in Aortic Aneurysms and Dissections. Circulation. 2023;148:959–977. doi: 10.1161/CIRCULATIONAHA.123.063332 - DOI - PMC - PubMed

[3] Dobnikar L, Taylor AL, Chappell J, Oldach P, Harman JL, Oerton E, Dzierzak E, Bennett MR, Spivakov M, Jorgensen HF. Disease-relevant transcriptional signatures identified in individual smooth muscle cells from healthy mouse vessels. Nat Commun. 2018;9:4567. doi: 10.1038/s41467-018-06891-x - DOI - PMC - PubMed

[4] Dobnikar L, Taylor AL, Chappell J, Oldach P, Harman JL, Oerton E, Dzierzak E, Bennett MR, Spivakov M, Jorgensen HF. Disease-relevant transcriptional signatures identified in individual smooth muscle cells from healthy mouse vessels. Nat Commun. 2018;9:4567. doi: 10.1038/s41467-018-06891-x - DOI - PMC - PubMed

[5] Pan X, Zhang R, Lu B, Chen S, Chen H, Li M, Qin L, Song Z, Yang Y, Wang Z, et al. SM22alpha-Lineage Perivascular Stromal Cells Contribute to Abdominal Aortic Aneurysm. Circ Res. 2025. doi: 10.1161/CIRCRESAHA.124.325750 - DOI - PubMed

[6] Pan X, Zhang R, Lu B, Chen S, Chen H, Li M, Qin L, Song Z, Yang Y, Wang Z, et al. SM22alpha-Lineage Perivascular Stromal Cells Contribute to Abdominal Aortic Aneurysm. Circ Res. 2025. doi: 10.1161/CIRCRESAHA.124.325750 - DOI - PubMed

[7] Golledge J Abdominal aortic aneurysm: update on pathogenesis and medical treatments. Nat Rev Cardiol. 2019;16:225–242. doi: 10.1038/s41569-018-0114-9 - DOI - PubMed

[8] Golledge J Abdominal aortic aneurysm: update on pathogenesis and medical treatments. Nat Rev Cardiol. 2019;16:225–242. doi: 10.1038/s41569-018-0114-9 - DOI - PubMed

[9] Qian W, Hadi T, Silvestro M, Ma X, Rivera CF, Bajpai A, Li R, Zhang Z, Qu H, Tellaoui RS, et al. Microskeletal stiffness promotes aortic aneurysm by sustaining pathological vascular smooth muscle cell mechanosensation via Piezo1. Nat Commun. 2022;13:512. doi: 10.1038/s41467-021-27874-5 - DOI - PMC - PubMed

[10] Qian W, Hadi T, Silvestro M, Ma X, Rivera CF, Bajpai A, Li R, Zhang Z, Qu H, Tellaoui RS, et al. Microskeletal stiffness promotes aortic aneurysm by sustaining pathological vascular smooth muscle cell mechanosensation via Piezo1. Nat Commun. 2022;13:512. doi: 10.1038/s41467-021-27874-5 - DOI - PMC - PubMed

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Achilles' Heel of Aortic Aneurysms: Adipose-Myofibroblast Differentiation

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Achilles' Heel of Aortic Aneurysms: Adipose-Myofibroblast Differentiation

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