Partial and maximal expiratory flow-volume curves in normal and asthmatic subjects before and after inhalation of metaproterenol
- PMID: 4053712
- DOI: 10.1378/chest.88.5.697
Partial and maximal expiratory flow-volume curves in normal and asthmatic subjects before and after inhalation of metaproterenol
Abstract
The effects of deep inspiration upon expiratory flow rates and response to inhaled metaproterenol were studied in normal and asthmatic subjects using partial (PEFV) and maximal (MEFV) expiratory flow volume curves. Routine pulmonary function tests and specific conductance were also measured. Prior to administration of metaproterenol, 18 of 24 normal subjects and 11 of 24 asthmatic subjects (p 0.05) had higher flow rates on MEFV than on PEFV curves. The 11 volume history responsive asthmatic subjects showed better lung function and more density-dependence of expiratory flow than the other 13 asthmatic subjects; furthermore, the effect of lung inflation was significantly larger in the volume history responsive asthmatic subjects than in the volume history responsive normal subjects. Responses to inhaled metaproterenol were much larger on PEFV than MEFV curves; nevertheless, differences between normal and asthmatic subjects in metaproterenol responsiveness were less using PEFV curves. Thus, the use of PEFV curve measurement did not facilitate the detection of individual asthmatic responses to inhaled metaproterenol.
Similar articles
-
Evaluation of a metered-dose aerosol delivery system using partial flow-volume curves.Am Rev Respir Dis. 1987 Mar;135(3):741-3. doi: 10.1164/arrd.1987.135.3.741. Am Rev Respir Dis. 1987. PMID: 3826899 Clinical Trial.
-
Effects of thoracic gas compression on maximal and partial flow-volume maneuvers.J Appl Physiol (1985). 1989 Aug;67(2):780-5. doi: 10.1152/jappl.1989.67.2.780. J Appl Physiol (1985). 1989. PMID: 2793680
-
Effect of a deep inspiration on expiratory flow in normals and patients with chronic obstructive pulmonary disease.Bull Eur Physiopathol Respir. 1986 Mar-Apr;22(2):119-25. Bull Eur Physiopathol Respir. 1986. PMID: 3708185
-
Response to inhaled metaproterenol and isoproterenol in asthmatic and normal subjects.Chest. 1980 Jul;78(1):44-50. doi: 10.1378/chest.78.1.44. Chest. 1980. PMID: 7471844
-
[Analysis of maximal expiratory flow-volume curves--visual evaluation and quantitative evaluation].Nihon Eiseigaku Zasshi. 1991 Jun;46(2):625-34. doi: 10.1265/jjh.46.625. Nihon Eiseigaku Zasshi. 1991. PMID: 1890771 Review. Japanese.
Cited by
-
A novel hypothesis to explain the bronchconstrictor effect of deep inspiration in asthma.Thorax. 2002 Feb;57(2):116-9. doi: 10.1136/thorax.57.2.116. Thorax. 2002. PMID: 11828039 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical