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. 2025 Oct 8;74(11):1933-1935.
doi: 10.1136/gutjnl-2025-335810.

Validation of the CLIF-SIG score in patients with HBV-related acutely decompensated cirrhosis

Jiyang Chen #  1 , Xianbin Xu #  1 , Sisi Yang #  1 , Xia Yu  1 , Ferran Aguilar  2   3 , Joan Claria  2   3   4 , Jonel Trebicka  2   5 , Juan José Lozano  6 , Julia Sidorova  5 , Paolo Angeli  2   7 , Alberto Queiroz Farias  2   8 , Richard Moreau  2   9   10 , Wenyi Gu  11 , Zelu Meng  1 , Ying Nie  1 , Yining Zhang  1 , Xiaohan Qian  1 , Yu Shi  12 , Yida Yang  12
Affiliations

Validation of the CLIF-SIG score in patients with HBV-related acutely decompensated cirrhosis

Jiyang Chen et al. Gut. .
No abstract available

Keywords: CIRRHOSIS; GENETICS; HEPATITIS B; INFLAMMATION; LIVER FAILURE.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1. Validation of the CLIF-SIG score in patients with HBV-related acutely decompensated cirrhosis. (A) Heatmap displaying expression profiles of the 28 genes comprising the CLIF-SIG score across healthy controls (HC), patients with acute decompensation (AD) and acute-on-chronic liver failure (ACLF). (B) Distribution of CLIF-SIG scores across HC, AD and ACLF groups. (C) Comparison of CLIF-SIG scores among subgroups within the AD cohort, including SDC, UDC and pre-ACLF classifications. (D) Kaplan-Meier curves of 90-day transplant-mortality between patients with CLIF-SIG scores >0.386 and those with lower scores. (E, F) ROC curves of CLIF-SIG, MELD and MELD-Na scores in predicting 90-day mortality in the entire AD cohort (E) and in ACLF patients (F). (G) ROC curves of CLIF-SIG, MELD-Na and their combination in classifying AD severity. (H) ROC curves of CLIF-SIG, MELD-Na and their combination in predicting AD-ACLF progression. Results in B and C were presented as mean±SD. Statistical significance was determined using one-way ANOVA with Tukey’s multiple comparison test. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001. ANOVA, analysis of variance; AUC, area under the curve; CLIF, Chronic Liver Failure Consortium; HBV, hepatitis B virus; MELD, Model for End-Stage Liver Disease; ROC, receiver operating characteristic; SDC, stable decompensated cirrhosis; SIG, systemic inflammation gene; UDC, unstable decompensated cirrhosis.
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References

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