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. 2025 Sep;27(9):5346-5350.
doi: 10.1111/dom.16546. Epub 2025 Jun 19.

Association between retinal microvasculature and cerebral small vessel function in type 2 diabetes: An ultrahigh field MRI study

Jan F de Leijer  1 , Stanley D T Pham  2 , Tessa A C M Vissers  1 , Lieza G Exalto  2 , Reinier O Schlingemann  3   4 , Jeroen S W Siero  5 , Jaco J M Zwanenburg  5 , Rafael Simó  6 , Noemi Lois  7 , Thomas T van Sloten  1 , Geert Jan Biessels  2 ; RECOGNISED consortium
Affiliations

Association between retinal microvasculature and cerebral small vessel function in type 2 diabetes: An ultrahigh field MRI study

Jan F de Leijer et al. Diabetes Obes Metab. 2025 Sep.
No abstract available

Keywords: diabetes complications; long‐standing disease; observational study; type 2 diabetes.

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Conflict of interest statement

None.

Figures

FIGURE 1
FIGURE 1
Association between retinal microvascular parameters and cerebral small vessel function parameter. Standardized regression coefficients (β) with 95% confidence intervals (CIs) for the associations between retinal microvascular parameters (independent variables) and cerebral small vessel function parameters (dependent variables) obtained with age and sex‐adjusted linear regression models. Retinal vessel density, cerebral basal ganglia and semi‐oval blood flow velocity and cerebral white and grey matter blood‐oxygenation level‐dependent (BOLD) response were modelled per standard deviation (SD) decrease because lower values are considered worse for these parameters. Consequently, for all βs, a positive value indicates that a worse value of the retinal microvascular parameter corresponds to worse cerebral small vessel function.
See this image and copyright information in PMC

References

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