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Case Reports
. 2025 Jan-Dec:13:23247096251348909.
doi: 10.1177/23247096251348909. Epub 2025 Jun 20.

Primary Non-Hodgkin Lymphoma of the Liver and Gallbladder Diagnosed by Laparoscopic Segment 8 Subsegmentectomy and Cholecystectomy: A Rare Case Report

Toshikatsu Nitta  1 , Masatsugu Ishii  1 , Masataka Taki  1 , Ryutaro Kubo  1 , Akitada Sada  1 , Atsushi Takeshita  2 , Takashi Ishibashi  1
Affiliations
Case Reports

Primary Non-Hodgkin Lymphoma of the Liver and Gallbladder Diagnosed by Laparoscopic Segment 8 Subsegmentectomy and Cholecystectomy: A Rare Case Report

Toshikatsu Nitta et al. J Investig Med High Impact Case Rep. 2025 Jan-Dec.

Abstract

A 71-year-old Japanese woman presented to our hospital to consult for a gallbladder polyp detected on a routine ultrasound in 2024. We found a sized-up gallbladder polyp and a liver tumor. She underwent laparoscopic segment 8 subsegmentectomy and cholecystectomy for suspected malignancy. Pathology revealed aggressive follicular lymphoma of the liver and gallbladder. Immunohistochemical staining was positive for CD10, CD20, CD23, CD79a, BCL-2, and BCL-6, and negative for CD3, CD5, and cyclin-D1. Primary hepatic lymphoma and gallbladder polyp are accidental, and diagnosis is difficult without tissue biopsy or specimens. Laparoscopic hepatectomy facilitates accurate diagnosis and early postoperative recovery, enabling rapid chemotherapy administration.

Keywords: liver tumor; lymphoma; primary hepatic lymphoma.

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Conflict of interest statement

Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Laboratory findings.
Figure 2.
Figure 2.
Preoperative abdominal computed tomography. Contrast computed tomography indicated a hypoenhancing hypodense lesion in segment VIII of the liver (yellow arrow).
Figure 3.
Figure 3.
Preoperative abdominal MRI. MRI revealed a liver tumor that showed a low signal on T1 images and uneven internal enhancement after contrast administration with unclear edges. MRI, magnetic resonance imaging.
Figure 4.
Figure 4.
Preoperative fluorodeoxyglucose PET-CT. Fluorodeoxyglucose PET confirmed abnormal metabolic activity with no standardized uptake in the segment VIII (S8) lesion (white arrow). PET-CT, positron emission tomography-computed tomography.
Figure 5.
Figure 5.
Resected specimen. The resected specimen was 1.8 × 1.6 cm and we suspected it to be a mixed-type hepatocellular carcinoma.
Figure 6.
Figure 6.
Histological appearance (hematoxylin and eosin staining ×40). Pathological examination revealed aggressive FL of the liver (a) and gallbladder (b), which showed a tumor-like structure mimicking the normal germinal center of a lymphoid follicle. FL, follicular lymphoma.
Figure 7.
Figure 7.
Immunohistochemical findings (both staining ×40). Immunohistochemical staining was positive for CD10, CD20, CD23, CD79a, BCL-2, and BCL-6, and negative for CD3, CD5, and cyclin-D1. BCL-2 and CD10 were positive for B-cell lymphoma.
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