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Review
. 2025 Jun;58(6):e13806.
doi: 10.1111/cpr.13806. Epub 2025 Jan 26.

Organoids in Haematologic Research: Advances and Future Directions

Liangzheng Chang  1   2 , Lu Li  1   2 , Yuling Han  3   4   5 , Hui Cheng  1   2 , Liuliu Yang  1   2
Affiliations
Review

Organoids in Haematologic Research: Advances and Future Directions

Liangzheng Chang et al. Cell Prolif. 2025 Jun.

Abstract

Organoid technology, as a revolutionary biomedical tool, has shown immense potential in haematological research in recent years. By using three-dimensional (3D) cell culture systems constructed from pluripotent stem cells (PSCs) or adult stem cells (ASCs), organoids can highly mimic the characteristics of in vivo organs, thereby offering significant potential for investigating human organ development, disease processes and treatment strategies. This review introduces the development of organoids and focuses on their progress in haematological research, including haematopoietic-related organoids, immune-related organoids and organoids used for studying blood system diseases. It discusses the prospects, challenges and future outlook of organoids in the field of haematology. This review aims to provide the latest advancements and future directions of organoid technology in haematological research, offering references and insights into further exploration in this field.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
The chronological history of the development of organoids.
FIGURE 2
FIGURE 2
Organoids in haematological research.
FIGURE 3
FIGURE 3
Timeline of organoid development in haematological research.
FIGURE 4
FIGURE 4
The future development of organoids and their application in haematology.
See this image and copyright information in PMC

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