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Review
. 2025 Jun 5:16:1591234.
doi: 10.3389/fimmu.2025.1591234. eCollection 2025.

Use of anakinra in cryopyrin-associated periodic syndromes: case report and review of literature

Marta Salas Sánchez  1 , Elena García-Martínez  2   3 , Héctor Balastegui Martín  4 , María Esther Durán-García  3   5 , Cristina Lavilla Olleros  1   3
Affiliations
Review

Use of anakinra in cryopyrin-associated periodic syndromes: case report and review of literature

Marta Salas Sánchez et al. Front Immunol. .

Abstract

Cryopyrin-associated periodic syndrome is a rare autoinflammatory syndrome caused by a dysregulation of cytokine signaling pathways, particularly of the interleukin-1β production. Symptoms typical appear early in life and include recurrent fever, arthralgia, and cutaneous rash, often accompanied by systemic manifestations and progressive end-organ damage resulting from chronic inflammation. Interleukin- targeted therapy constitutes the basis for treatment, and can lead to complete resolution of symptoms. We report a case of a 66-year-old man with cryopyrin-associated periodic syndrome related to V198M mutation, successfully treated with anakinra, an interleukin- 1 inhibitor frequently used in rheumatoid arthritis.

Keywords: CAPS; anakinra; autoinflammatory disease; case report; cryopyrin-associated periodic syndrome.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Figure 1
Clinical and therapeutic course.
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