Cross-talk between Pseudomonas aeruginosa and urinary tract infections

Abstract

Pseudomonas aeruginosa, a key member of the ESKAPE pathogen group, is a common cause of urinary tract infections (UTIs), particularly in patients with indwelling urinary catheters. Due to its large genome, P. aeruginosa has a high potential for genetic mutations, enabling the development of multidrug resistance. Additionally, it produces a variety of virulence factors, which contribute to persistent and often refractory infections. While UTIs caused by Escherichia coli have been extensively studied, those caused by P. aeruginosa remain less well understood. Understanding the mechanisms underlying the occurrence and progression of P. aeruginosa-associated UTIs, as well as the evolution of its antimicrobial resistance, is crucial for developing more effective treatment strategies. This paper provides an overview of the interaction between P. aeruginosa and UTIs, offering insights that could aid in more effective management and eradication of P. aeruginosa in the urinary tract.

Keywords: Pseudomonas aeruginosa; Anti-biofilm; Antimicrobial resistance; Urinary tract infections; Virulence factors.