Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Jun 20;45(1):249.
doi: 10.1007/s10792-025-03633-z.

Effect of vitreopapillary interface adhesions on optic disc: an OCTA study

Hazan Gül Kahraman  1 , Yusuf Ziya Güven  2 , Feray Koç  2
Affiliations

Effect of vitreopapillary interface adhesions on optic disc: an OCTA study

Hazan Gül Kahraman et al. Int Ophthalmol. .

Abstract

Purpose: This study aims to investigate the effects of vitreopapillary adhesion (VPA) on the optic disc (OD) microvascular structure using optical coherence tomography angiography (OCTA).

Methods: Thirty five patients with complete PVD at the posterior pole and residual optic disc adhesion (stage 3) (using the posterior vitreous detachment (PVD) staging by Uchino et al.) were included in the study. As a control group, 34 healthy individuals were included. RNFL thickness, rim area, disc area, cup/disc ratio, perfusion and flux index measurements were analysed with an optical coherence tomography angiography (OCTA).

Results: While there was no statistically significant difference between the retinal nerve fiber layer thicknesses of both groups except the upper quadrant, the upper quadrant of RNFL thickness was found to be statistically significantly thinner in the vitreo-papillary adhesion (VPA) group. Mean value of disc area was 1.94 ± 0.38 in the adhesion group and 2.17 ± 0.42 in the control group (p = 0.060). Cup/disc ratios of VPA and control groups were 0.16 ± 0.15, 0.44 ± 0.14, respectively (p = 0.000).Cup volumes were also statistically significantly smaller in the adhesion group in parallel with the c/d ratio (0.02 ± 0.04, 0.16 ± 0.19 p = 0.000). Optic disc perfusions were 43.77% ± 2.22% in the adhesion group and 45.31 ± 1.20% in the control group (p = 0.003).

Conclusion: The significantly lower C/D ratio and cup volume in patients with vitreopapillary adhesion indicates that adhesion may occur more frequently in especially crowded discs. Although OCTA may be misleading in VPA patients, close monitoring of increased synretic vitreous gel traction on the OD with OCTA may be beneficial especially in patients with completed macular PVD. Monitoring VPA with OCTA may provide valuable insights into early vascular alterations that may contribute to non-arteritic anterior ischemic optic neuropathy (NAION) or papillary vitreous detachment neuropathy.

Keywords: Crowded disc; Optical coherence tomography angiography; Vitreopapillary adhesion.

PubMed Disclaimer

Conflict of interest statement

Declarations. Conflict of interest: The authors declare that they have no conflict of interest.

References

    1. Bishop PN (2000) Structural macromolecules and supramolecular organisation of the vitreous gel. Prog Retin Eye Res 19(3):323–344 - DOI - PubMed
    1. Katz B, Hoyt WF (1995) Intrapapillary and peripapillary hemorrhage in young patients with incomplete posterior vitreous detachment. Signs Vitreopapill Tract Ophthalmol 102(2):349–354
    1. Uchino E, Uemura A, Ohba N (2001) Initial stages of posterior vitreous detachment in healthy eyes of older persons evaluated by optical coherence tomography. Arch Ophthalmol 119(10):1475–1479 - DOI - PubMed
    1. Ang AC, Hsieh YT, Tsui MC, Lai TT, Yang CM (2022) Idiopathic macular hole without vitreomacular separation. Ophthalmologica 245(2):187–193 - DOI - PubMed
    1. Breazzano MP, Fang H, Robinson MR, Abraham JL, Barker-Griffith AE (2016) Vitreomacular attachment ultrastructure and histopathological correlation. Curr Eye Res 41(8):1098–1104 - DOI - PubMed

LinkOut - more resources