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. 2025 Sep:351:116585.
doi: 10.1016/j.psychres.2025.116585. Epub 2025 Jun 11.

Childhood adversities and their associations with mental disorders in the World Mental Health International College Student surveys initiative

Mathilde M Husky  1 Sue Lee  2 Nancy A Sampson  2 Shelby Borowski  2 Yesica Albor  3 Ahmad N Alhadi  4 Jordi Alonso  5 Nouf K Al-Saud  6 Yasmin A Altwaijri  6 Claes Andersson  7 Lukoye Atwoli  8 Caroline Ayuya Muaka  9 Patricia M Báez-Mansur  10 Laura Ballester  11 Jason Bantjes  12 Harald Baumeister  13 Marcus Bendtsen  14 Corina Benjet  3 Anne H Berman  15 Ronny Bruffaerts  16 Paula Carrasco  17 Silver C N Chan  18 Irina F Cohut  19 María Anabell Covarrubias Díaz Couder  20 Paula Cristóbal-Narváez  21 Marcelo A Crockett  22 Pim Cuijpers  23 Oana A David  24 Dong Dong  25 David D Ebert  26 Carlos G Forero  27 Jorge Gaete  28 Margalida Gili  29 Raúl Gutiérrez-García  30 Josep Maria Haro  21 Penelope Hasking  31 Xanthe Hunt  32 Florence Jaguga  33 Leontien Jansen  16 Álvaro I Langer  34 Irene Léniz  35 Yan Liu  36 Christine Lochner  37 Scarlett Mac-Ginty  38 Vania Martínez  39 Andre Mason  40 Muthoni Mathai  41 Margaret McLafferty  42 Elaine K Murray  43 Catherine M Musyoka  41 Cătălin Nedelcea  44 Daniel Núñez  45 Siobhan M O'Neill  46 José A Piqueras  47 Codruta A Popescu  48 Charlene Rapsey  49 Kealagh Robinson  50 Tiscar Rodriguez-Jimenez  51 Wylene Saal  52 Damian Scarf  53 Oi-Ling Siu  54 Dan J Stein  55 Sascha Y Struijs  56 Cristina T Tomoiaga  57 Karla Patricia Valdés-García  58 Eunice Vargas-Contreras  59 Shelby Vereecke  60 Daniel V Vigo  61 Angel Y Wang  60 Samuel Y S Wong  25 Ronald C Kessler  62 World Mental Health International College Student collaborators
Affiliations

Childhood adversities and their associations with mental disorders in the World Mental Health International College Student surveys initiative

Mathilde M Husky et al. Psychiatry Res. 2025 Sep.

Abstract

Purpose: This study investigates associations of childhood adversities (CAs) with lifetime prevalence, 12-month prevalence, and 12-month persistence of mental disorders in a large cross-national sample of university students.

Methods: Data came from epidemiologic surveys carried out by the World Mental Health International College Student (WMH-ICS)Initiative across 18 countries (n=60,719). The web-based surveys screened for lifetime and 12-month prevalence and age-of-onset of common DSM-5 disorders (Major Depressive Disorder, Bipolar I/II Disorder, Generalized Anxiety Disorder, Panic Disorder, Posttraumatic Stress Disorder, Alcohol and Drug Use disorders, Attention-Deficit/Hyperactivity Disorder) and five types of CAs (family dysfunction, emotional abuse, physical abuse, sexual abuse, neglect). Multivariable Poisson regression models estimated associations of CA type, number, and frequency with disorders.

Results: The majority of incoming students reported exposure to at least one CA (64.9%), including 50.0 % family dysfunction, 42.2 % emotional abuse, 21.2 % physical abuse, 18.8 % neglect, and 5.0 % sexual abuse. Lifetime and 12-month disorders were significantly associated with CAs in multivariable models, although associations with disorder persistence were weaker. Population attributable risk proportions of 12-month disorders associated with CAs were in the range of 40.7-61.0 % for anxiety and mood disorders and 13.5-55.2 % for substance use disorders.

Conclusion: Six out of ten university students arrive at university having been exposed to CAs. These students have substantially higher risk of mental disorders than other students, primarily due to associations with lifetime risk rather than persistence. Given the considerable distress and impairment caused by mental disorders, these results underscore the need for primary and secondary prevention efforts.

Keywords: ADHD; Anxiety; Childhood adversities; Depression; Mental disorders; Persistence; Substance use disorder; University students.

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Conflict of interest statement

Declaration of competing interest RB reports grant funding from Eli Lilly (IIT-H6U-BX-I002). DDE has served as a consultant to/on the scientific advisory boards of Sanofi, Novartis, Minddistrict, Lantern, Schoen Kliniken, Ideamed and German health insurance companies (BARMER, Techniker Krankenkasse) and a number of federal chambers for psychotherapy. He is also shareholder of "GET.ON Institut für Online Gesundheitstrainings GmbH für Gesundheitstrainings online GmbH" (HelloBetter), which aims to implement scientific findings related to digital health interventions into routine care. XH has received grants from Sexual Violence Research Institute, Volkswagen Foundation, Wellspring Philanthropies, Foreign, Commonwealth and Development Office (UK government), PANDA Holding Limited, National Research Foundation of South Africa, Center for Inclusive Policy. XH reports consulting fees from Mastercard Foundation, Missing Billion Initiative, UNICEF, International Food Policy Research Institute and the African Union. Hunt has received funding support to attend conferences from Mastercard Foundation and Charité University (Germany). MMH reports consulting fees from Child Mind Institute, New York. In the past 3 years, RCK was a consultant for Cambridge Health Alliance, Canandaigua VA Medical Center, Child Mind Institute, Holmusk, Massachusetts General Hospital, Partners Healthcare, Inc., RallyPoint Networks, Inc., Sage Therapeutics and University of North Carolina. He has stock options in Cerebral Inc., Mirah, PYM (Prepare Your Mind), Roga Sciences and Verisense Health. DJS has received consultancy honoraria from Discovery Vitality, Johnson & Johnson, Kanna, L’Oreal, Lundbeck, Orion, Servier, Seaport Therapeutics, Takeda, Vistagen, and Wellcome. DVV reports grant support from Health Canada, Provincial Health Services Authority and an internal research grant from the University of British Columbia. The Province of BC and Vancouver Coastal Health Authority made payments to Dr. Vigo with respect to contracts for projects related to mental health service provision. The remaining authors have no conflicts of interest to report.

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