The TFIID complex is a new autoantibody target in systemic sclerosis

Jean-Baptiste Vulsteke¹, Birthe Michiels², Vanessa Smith³, Yves Piette⁴, Marie Vanthuyne⁵, Carole Lacout⁶, Antoine Brochard⁶, Mohammed Tikly⁷, Jonas De Leeuw¹, Doreen Dillaerts⁸, Tom Dehaemers⁸, Petra De Haes⁹, Jan L Lenaerts¹⁰, Daniel Blockmans¹¹, Neil McHugh¹², Sarah Tansley¹², Emeline Vinatier¹³, Frédéric Houssiau¹⁴, Carolien Bonroy¹⁵, Ellen De Langhe¹⁶, Xavier Bossuyt¹⁷

Affiliations

¹ Rheumatology, University Hospitals Leuven, Leuven, Belgium; Clinical and Diagnostic Immunology, Department Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.
² Clinical and Diagnostic Immunology, Department Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium; Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium.
³ Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium; Rheumatology, Ghent University Hospital, Ghent, Belgium; Unit for Molecular Immunology and Inflammation, VIB Inflammation Research Center (IRC), Ghent, Belgium; European Reference Network on Rare and Complex Connective Tissue and Musculoskeletal Diseases (ERN ReCONNET).
⁴ Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium; Rheumatology, Ghent University Hospital, Ghent, Belgium; European Reference Network on Rare and Complex Connective Tissue and Musculoskeletal Diseases (ERN ReCONNET); Rheumatology, AZ Sint-Jan Brugge AV, Bruges, Belgium.
⁵ European Reference Network on Rare and Complex Connective Tissue and Musculoskeletal Diseases (ERN ReCONNET); Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium; Rheumatology, CHU Mont Godinne, Yvoir, Belgium.
⁶ Internal Medicine, Immunology, Centre Hospitalier Universitaire d' Angers, Angers, France.
⁷ Division of Rheumatology, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
⁸ Clinical and Diagnostic Immunology, Department Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.
⁹ European Reference Network on Rare and Complex Connective Tissue and Musculoskeletal Diseases (ERN ReCONNET); Dermatology, University Hospitals Leuven, Leuven, Belgium; Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.
¹⁰ Rheumatology, University Hospitals Leuven, Leuven, Belgium.
¹¹ European Reference Network on Rare and Complex Connective Tissue and Musculoskeletal Diseases (ERN ReCONNET); General Internal Medicine, University Hospitals Leuven, Leuven, Belgium; Laboratory for Clinical Infectious and Inflammatory Disorders, KU Leuven, Leuven, Belgium.
¹² Department of Life Sciences, University of Bath, Bath, UK.
¹³ Laboratoire d'Immunologie et d'Allergologie, Centre Hospitalier Universitaire d'Angers, Angers, France.
¹⁴ European Reference Network on Rare and Complex Connective Tissue and Musculoskeletal Diseases (ERN ReCONNET); Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
¹⁵ Diagnostic Sciences, Ghent University, Ghent, Belgium; Laboratory Medicine, Ghent University Hospital, Ghent, Belgium.
¹⁶ Rheumatology, University Hospitals Leuven, Leuven, Belgium; European Reference Network on Rare and Complex Connective Tissue and Musculoskeletal Diseases (ERN ReCONNET); Skeletal Biology and Engineering Research Center, KU Leuven, Leuven, Belgium.
¹⁷ Clinical and Diagnostic Immunology, Department Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium; Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium. Electronic address: xavier.bossuyt@uzleuven.be.

PMID: 40541453
DOI: 10.1016/j.ard.2025.05.008

The TFIID complex is a new autoantibody target in systemic sclerosis

Jean-Baptiste Vulsteke et al. Ann Rheum Dis. 2025.

. 2025 Jun 19:S0003-4967(25)00968-9.

doi: 10.1016/j.ard.2025.05.008. Online ahead of print.

Authors

Affiliations

¹ Rheumatology, University Hospitals Leuven, Leuven, Belgium; Clinical and Diagnostic Immunology, Department Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.
² Clinical and Diagnostic Immunology, Department Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium; Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium.
³ Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium; Rheumatology, Ghent University Hospital, Ghent, Belgium; Unit for Molecular Immunology and Inflammation, VIB Inflammation Research Center (IRC), Ghent, Belgium; European Reference Network on Rare and Complex Connective Tissue and Musculoskeletal Diseases (ERN ReCONNET).
⁴ Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium; Rheumatology, Ghent University Hospital, Ghent, Belgium; European Reference Network on Rare and Complex Connective Tissue and Musculoskeletal Diseases (ERN ReCONNET); Rheumatology, AZ Sint-Jan Brugge AV, Bruges, Belgium.
⁵ European Reference Network on Rare and Complex Connective Tissue and Musculoskeletal Diseases (ERN ReCONNET); Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium; Rheumatology, CHU Mont Godinne, Yvoir, Belgium.
⁶ Internal Medicine, Immunology, Centre Hospitalier Universitaire d' Angers, Angers, France.
⁷ Division of Rheumatology, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
⁸ Clinical and Diagnostic Immunology, Department Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.
⁹ European Reference Network on Rare and Complex Connective Tissue and Musculoskeletal Diseases (ERN ReCONNET); Dermatology, University Hospitals Leuven, Leuven, Belgium; Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.
¹⁰ Rheumatology, University Hospitals Leuven, Leuven, Belgium.
¹¹ European Reference Network on Rare and Complex Connective Tissue and Musculoskeletal Diseases (ERN ReCONNET); General Internal Medicine, University Hospitals Leuven, Leuven, Belgium; Laboratory for Clinical Infectious and Inflammatory Disorders, KU Leuven, Leuven, Belgium.
¹² Department of Life Sciences, University of Bath, Bath, UK.
¹³ Laboratoire d'Immunologie et d'Allergologie, Centre Hospitalier Universitaire d'Angers, Angers, France.
¹⁴ European Reference Network on Rare and Complex Connective Tissue and Musculoskeletal Diseases (ERN ReCONNET); Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
¹⁵ Diagnostic Sciences, Ghent University, Ghent, Belgium; Laboratory Medicine, Ghent University Hospital, Ghent, Belgium.
¹⁶ Rheumatology, University Hospitals Leuven, Leuven, Belgium; European Reference Network on Rare and Complex Connective Tissue and Musculoskeletal Diseases (ERN ReCONNET); Skeletal Biology and Engineering Research Center, KU Leuven, Leuven, Belgium.
¹⁷ Clinical and Diagnostic Immunology, Department Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium; Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium. Electronic address: xavier.bossuyt@uzleuven.be.

PMID: 40541453
DOI: 10.1016/j.ard.2025.05.008

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Conflict of interest statement

Competing interests J-BV reports financial support was provided by Research Foundation Flanders. VS has received research grants, consulting fees, and support from Boehringer-Ingelheim, Janssen-Cilag, Argenx BV, WebMD Global LLC, and BKC Moving Media Makers BV (outside the scope from the submitted work). NM was member of the data safety monitoring board for NIHIR funded Astute Trial (outside the scope from the submitted work). XB was part of a scientific advisory committee for Inova Diagnostics and Thermo Fisher (outside the scope from the submitted work).

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The TFIID complex is a new autoantibody target in systemic sclerosis

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The TFIID complex is a new autoantibody target in systemic sclerosis

Authors

Affiliations

Conflict of interest statement

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