Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1985;29(1):85-9.
doi: 10.1007/BF00547374.

Pharmacokinetics of triamcinolone acetonide and its phosphate ester

H Möllmann, P Rohdewald, E W Schmidt, V Salomon, H Derendorf

Pharmacokinetics of triamcinolone acetonide and its phosphate ester

H Möllmann et al. Eur J Clin Pharmacol. 1985.

Abstract

Triamcinolone acetonide in the form of its phosphate ester was given intravenously in two different doses (10 mg/kg and 80 mg). Plasma levels of the ester and triamcinolone acetonide were measured and pharmacokinetic parameters were calculated. The pharmacokinetics both of the phosphate and the free alcohol were dose-dependent. No unchanged ester was found in the urine, indicating complete conversion of the pro-drug. Triamcinolone was not a major metabolite of triamcinolone acetonide in humans. Renal clearance was low and independent of the dose. Only about 1% of the dose was found in the urine as triamcinolone acetonide.

PubMed Disclaimer

References

    1. Clin Pharmacol Ther. 1985 May;37(5):502-7 - PubMed
    1. J Pharm Biomed Anal. 1986;4(2):197-206 - PubMed
    1. Arzneimittelforschung. 1969 Mar;19(3):340-2 - PubMed
    1. Arzneimittelforschung. 1982;32(8):832-4 - PubMed
    1. J Pharm Sci. 1978 Dec;67(12):1687-91 - PubMed

LinkOut - more resources