Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1985 Oct 8;116(1-2):187-90.
doi: 10.1016/0014-2999(85)90203-1.

Polyamines and putreanine relax respiratory tract smooth muscle in the guinea-pig

E W Chideckel, J S Fedan, P Mike

Polyamines and putreanine relax respiratory tract smooth muscle in the guinea-pig

E W Chideckel et al. Eur J Pharmacol. .

Abstract

Spermidine, spermine, and putreanine, a metabolite of spermidine, caused transient relaxation of the isolated guinea-pig trachealis. The spermidine effect was not blocked by ouabain, propranolol or indomethacin. Spermidine treatment was shown to desensitize the tissue to subsequent additions of spermidine. After exposure to spermidine and repeated washes with spermidine-free solution, trachealis responded to KCl (30 mM) with a paradoxical relaxation. This relaxation was not blocked by propranolol, ouabain or indomethacin.

PubMed Disclaimer

Publication types

LinkOut - more resources