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Review
. 2025 Jun 20.
doi: 10.1007/s00266-025-04972-z. Online ahead of print.

Microneedling for Facial Rejuvenation: A Systematic Review

Jose A Foppiani #  1   2   3 , James E Fanning #  1 , Kassandra Beltran  3 , Otakar Raska  3   4 , Angelica Hernandez Alvarez  1 , Iulianna Taritsa  1 , Erin Kim  1 , Maria-Jose Escobar  1 , Daniela Lee  1 , Umar Choudry  2 , Samuel J Lin  5 ; Otakar Raska
Collaborators, Affiliations
Review

Microneedling for Facial Rejuvenation: A Systematic Review

Jose A Foppiani et al. Aesthetic Plast Surg. .

Abstract

Background: Microneedling (MN) has risen in popularity as a non-surgical treatment option for facial skin aging. We aimed to evaluate patient-reported outcomes (PROMs) and safety profiles associated with MN.

Methods: A systematic review was conducted adhering to PRISMA guidelines. Articles were screened for relevance in a two-stage process. Descriptive statistics and a proportion meta-analysis was utilized for patient satisfaction using Stata statistical software.

Results: Of 346 studies identified, a total of 21 articles reporting outcomes of 723 patients undergoing MN for facial rejuvenation were included for review and meta-analysis. The patient cohort was majority female (72%), and the average age was 48 years. The most common esthetic study endpoints were wrinkling (71%, 15/21), skin texture (33%, 7/21), photoaging (29%, 6/21), and skin laxity (14%, 3/21). The majority of trials (90%, 19/21) treated patients with multiple MN sessions, and these studies' treatment schedules also varied by number and timing of sessions. Pooled meta-analysis revealed that 83% of patients reported satisfaction with their treatment (95% CI [0.76; 0.88]). The most common reported adverse effects were transient erythema (6.8%), scaling (1.7%), burning sensation (1.5%), and pruritus (0.4%).

Conclusion: Our meta-analysis revealed that MN is associated with high patient satisfaction and low rates of adverse events. High patient satisfaction coupled with a low incidence of adverse events supports MN as a viable non-surgical treatment option for facial rejuvenation. However, the lack of standardized measures for esthetic outcomes warrants continued research to better determine its efficacy in treating signs of facial aging.

Level of evidence iv: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

Keywords: Aging; Esthetic; Facial rejuvenation; Microneedling; Plastic surgery.

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Conflict of interest statement

Declarations. Conflict of Interest: The authors declare that they have no conflicts of interest to disclose. Ethical Approval: The article does not contain any studies with human participants or animals performed by any of the authors. Informed Consent: For this type of study, informed consent is not required.

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