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Observational Study
. 2025 Oct;40(10):3263-3271.
doi: 10.1007/s00467-025-06860-9. Epub 2025 Jun 21.

Advanced hemodynamic monitoring: feasibility of leveraging non-invasive electrocardiometry in critically ill pediatric patients requiring continuous kidney replacement therapy

Anna M Lang  1 , Ayse Akcan-Arikan  2   3 , Christin Silos  3 , Jack F Price  4 , Srivaths Poyyapakkam  3 , Joey Alge  3 , Sameer Thadani  2   3
Affiliations
Observational Study

Advanced hemodynamic monitoring: feasibility of leveraging non-invasive electrocardiometry in critically ill pediatric patients requiring continuous kidney replacement therapy

Anna M Lang et al. Pediatr Nephrol. 2025 Oct.

Abstract

Background: Hemodynamic instability occurs in children receiving continuous kidney replacement therapy (CKRT). Electrocardiometry can help characterize hemodynamics beyond traditional blood pressure (BP) and heart rate (HR). We aimed to assess the feasibility and correlations of hemodynamic measurements obtained using electrocardiometry in children receiving CKRT.

Methods: Prospective single-center observational study of pediatric patients receiving CKRT between 11/2019 and 3/2021. Patients who received extracorporeal membranous oxygenation, ventricular assist device, pacemaker, apheresis, no invasive BP, and COVID-19 were excluded. Electrocardiometry measured cardiac index (CI), HR, stroke volume variability (SVV), stroke volume index (SVI), and systemic vascular resistance index (SVRI) continuously; data were aggregated into 1-h epochs, and correlation coefficients were computed using Spearman's rank test.

Results: Seventeen patients with a median age of 43 months (IQR 13-122). Median weight and fluid overload at CKRT start were 13.9 kg (IQR 8.79-29.80) and 14.4% (IQR 2.4-25.6%) + 171.46 mL/kg (IQR 31.10-307.41), respectively. All measurements obtained via ICON were of high quality and no adverse events were identified. CI had a negative correlation with SVRI (r = - 0.67) and had a positive correlation with SVI (r = 0.83) and mean arterial pressure (MAP) (r = 0.63). HR did not correlate with any hemodynamic variables, while MAP only correlated with SVI (r = 0.63).

Conclusions: Electrocardiometry can assess the hemodynamic profile of children receiving CKRT. Compensatory cardiovascular changes remain intact in children receiving CKRT, as evidenced by correlations between SVI, SVRI, CI, and MAP. Future studies should investigate how this technology could enable more individualized CKRT prescriptions and improve patient outcomes.

Keywords: Continuous kidney replacement therapy; Electrocardiometry; Hemodynamics; Hypotension.

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Conflict of interest statement

Declarations. Conflict of interest: The authors declare no competing interests.

References

    1. Kaddourah A, Basu RK, Bagshaw SM et al (2017) Epidemiology of acute kidney injury in critically ill children and young adults. N Engl J Med 376:11–20. https://doi.org/10.1056/NEJMoa1611391 - DOI - PubMed
    1. Basu RK, Wheeler DS, Goldstein S, Doughty L (2011) Acute renal replacement therapy in pediatrics. Int J Nephrol 2011:785392. https://doi.org/10.4061/2011/785392 - DOI - PubMed - PMC
    1. Douvris A, Zeid K, Hiremath S et al (2019) Mechanisms for hemodynamic instability related to renal replacement therapy: a narrative review. Intensive Care Med 45:1333–1346. https://doi.org/10.1007/s00134-019-05707-w - DOI - PubMed - PMC
    1. Robinson CH, Jeyakumar N, Luo B et al (2021) Long-term kidney outcomes following dialysis-treated childhood acute kidney injury: a population-based cohort study. J Am Soc Nephrol 32:2005–2019. https://doi.org/10.1681/ASN.2020111665 - DOI - PubMed - PMC
    1. Santiago MJ, López-Herce J, Urbano J et al (2009) Complications of continuous renal replacement therapy in critically ill children: a prospective observational evaluation study. Crit Care 13:R184. https://doi.org/10.1186/cc8172 - DOI - PubMed - PMC

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