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Randomized Controlled Trial
. 2025 Nov:139:112855.
doi: 10.1016/j.nut.2025.112855. Epub 2025 May 26.

Boost or bust? A randomized crossover study on pre-exercise caffeine supplementation for fatigue management in basketball

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Randomized Controlled Trial

Boost or bust? A randomized crossover study on pre-exercise caffeine supplementation for fatigue management in basketball

Marco Pernigoni et al. Nutrition. 2025 Nov.

Abstract

The aim of this study was to to assess the effect of pre-exercise caffeine intake (CAF) on fatigue and recovery in basketball. Using a randomized crossover design, 14 amateur male players completed two basketball-specific training sessions (in-season phase, February-March 2024), preceded by CAF (3 mg/kg body weight) or placebo ingestion (CON). Countermovement jump height, 10- and 20-m sprint times, heart rate variability (Ln-rMSSD), static and dynamic muscle soreness, and perceived fatigue were recorded at pre-training, post-training and 24 h post-training to evaluate the effectiveness of caffeine supplementation. The results showed no significant differences between CAF and CON at corresponding time points for any variable (P > 0.05). Regarding the effect of time, the main findings indicate that countermovement jump (average percentage change [%∆] = -7% to -10%) and Ln-rMSSD (%∆ = -33% to -54%) decreased at post-training compared with all other time points (P < 0.001, effect size = 1.41-1.98), while 10-m sprint times deteriorated from pre-to-post-training (P = 0.029, effect size = 0.69, %∆ = -2%). Similarly, muscle soreness (%∆ = +171%) and perceived fatigue (%∆ = +156%) increased from pre-to-post-training in both interventions (P ≤ 0.006, r = 0.57-0.61), with static soreness in CON (%∆ = +127%) and dynamic soreness in CAF (%∆ = +139%) remaining higher than pre-training levels up to 24 h post-training (P ≤ 0.010, r = 0.53-0.58). These findings suggest that pre-exercise caffeine intake did not significantly affect markers of fatigue in amateur basketball players, either acutely or 24 h post-training.

Keywords: Ergogenic aids; Nutrition; Performance; Recovery; Team sports.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this article.

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