Complete genome sequence of a tetracycline-resistant Streptococcus mutans strain carrying the tet(M) gene

Affiliations

¹ Department of Biological Endodontics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan; Department of Bacteriology, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
² Department of Bacteriology, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
³ Center of Oral Clinical Examination, Hiroshima University Hospital, Hiroshima, Japan.
⁴ Antimicrobial Resistance Research Center, National Institute of Infectious Diseases, Higashi Murayama, Japan; Core Research Facilities, Research Center for Medical Sciences, The Jikei University School of Medicine, Tokyo, Japan.
⁵ Antimicrobial Resistance Research Center, National Institute of Infectious Diseases, Higashi Murayama, Japan; Project Research Centre for Nosocomial Infectious Diseases, Hiroshima University, Hiroshima, Japan.
⁶ Antimicrobial Resistance Research Center, National Institute of Infectious Diseases, Higashi Murayama, Japan.
⁷ Department of Biological Endodontics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
⁸ Department of Bacteriology, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan; Project Research Centre for Nosocomial Infectious Diseases, Hiroshima University, Hiroshima, Japan. Electronic address: mmatsuo@hiroshima-u.ac.jp.
⁹ Department of Bacteriology, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan; Project Research Centre for Nosocomial Infectious Diseases, Hiroshima University, Hiroshima, Japan.

PMID: 40545135
DOI: 10.1016/j.job.2025.100679

Complete genome sequence of a tetracycline-resistant Streptococcus mutans strain carrying the tet(M) gene

Saki Nishihama et al. J Oral Biosci. 2025 Sep.

. 2025 Sep;67(3):100679.

doi: 10.1016/j.job.2025.100679. Epub 2025 Jun 20.

Authors

Affiliations

¹ Department of Biological Endodontics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan; Department of Bacteriology, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
² Department of Bacteriology, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
³ Center of Oral Clinical Examination, Hiroshima University Hospital, Hiroshima, Japan.
⁴ Antimicrobial Resistance Research Center, National Institute of Infectious Diseases, Higashi Murayama, Japan; Core Research Facilities, Research Center for Medical Sciences, The Jikei University School of Medicine, Tokyo, Japan.
⁵ Antimicrobial Resistance Research Center, National Institute of Infectious Diseases, Higashi Murayama, Japan; Project Research Centre for Nosocomial Infectious Diseases, Hiroshima University, Hiroshima, Japan.
⁶ Antimicrobial Resistance Research Center, National Institute of Infectious Diseases, Higashi Murayama, Japan.
⁷ Department of Biological Endodontics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
⁸ Department of Bacteriology, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan; Project Research Centre for Nosocomial Infectious Diseases, Hiroshima University, Hiroshima, Japan. Electronic address: mmatsuo@hiroshima-u.ac.jp.
⁹ Department of Bacteriology, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan; Project Research Centre for Nosocomial Infectious Diseases, Hiroshima University, Hiroshima, Japan.

PMID: 40545135
DOI: 10.1016/j.job.2025.100679

Abstract

Introduction: Tetracyclines are widely used in dental treatment. Here, we report the genomic information of the tetracycline-resistant Streptococcus mutans strain, HSM45, for the first time.

Methods: Susceptibility to tetracycline was determined using the microdilution method. The complete genome sequence of HSM45 was determined and compared with public genome data.

Results: HSM45 was resistant to tetracycline. The tetracycline resistance gene tet(M) was carried by Tn916, a conjugative transposon that is widely found in Gram-positive bacteria.

Conclusion: This study showed that S. mutans can acquire tetracycline resistance and it can also be a source of horizontal transfer of resistance genes.

Keywords: Complete genome; Streptococcus mutans; Tetracycline; Tn916.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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Complete genome sequence of a tetracycline-resistant Streptococcus mutans strain carrying the tet(M) gene

Affiliations

Complete genome sequence of a tetracycline-resistant Streptococcus mutans strain carrying the tet(M) gene

Authors

Affiliations

Abstract

Conflict of interest statement

MeSH terms

Substances

LinkOut - more resources

Full Text Sources