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. 2025 Jun 23.
doi: 10.1002/mdc3.70187. Online ahead of print.

From Inner Sense to Outer Action: Interoception and Impulsive Compulsive Behavior Disorders in Parkinson's Disease

Chiara Baiano  1 , Francesca Morgante  2 , Diana Goeta  2 , Chiara Giacobbe  1 , Marianna Amboni  3 , Carmine Vitale  4   5 , Elena Makovac  6 , Benedetta Demartini  7 , Gabriella Santangelo  1 , Lucia Ricciardi  2
Affiliations

From Inner Sense to Outer Action: Interoception and Impulsive Compulsive Behavior Disorders in Parkinson's Disease

Chiara Baiano et al. Mov Disord Clin Pract. .

Abstract

Background: Impulsive-compulsive behavior disorders (ICBDs) in Parkinson's disease (PD) include impulse control disorders (ICDs) and compulsive behaviors, often linked to dopaminergic treatment and altered reward processing. Interoception, the perception of internal bodily signals, plays a key role in emotional regulation and decision-making. Neuroimaging studies suggest that alterations in interoceptive and reward-related brain circuits may underlie ICDs in PD. However, the relationship between interoception and ICDs remains underexplored.

Objective: To investigate the relationship between impulse control disorders (ICD) severity and interoceptive abilities-specifically interoceptive accuracy, insight, and self-reported interoception-in PD patients.

Methods: Fifty-one participants were assessed using the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease Rating Scale (QUIP-RS) alongside measures of interoceptive performance, anxiety, depression, and apathy.

Results: Higher ICD severity predicted increased interoceptive insight and sensibility. No significant link was found between ICD severity and interoceptive accuracy. Additionally, higher Levodopa Equivalent Daily Dose (LEDD) was related to lower interoceptive insight, suggesting a potential modulatory effect of dopaminergic therapy on meta-cognitive interoception.

Conclusions: These findings highlight the complex interplay between ICDs and interoception, suggesting that heightened self-reported interoception and interoceptive insight may reinforce impulsive behaviors in PD via enhanced bodily signal salience. This study contributes to understanding the characteristics of ICDs in PD, implicating reward-related circuits such as the insula and anterior cingulate cortex.

Keywords: Parkinson's disease; body signals; impulse control behaviors; impulsivity; interoception.

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References

    1. Weintraub D, Mamikonyan E, Papay K, Shea JA, Xie SX, Siderowf A. Questionnaire for impulsive‐compulsive disorders in Parkinson's disease‐rating scale. Mov Disord 2012;27:242–247.
    1. Cilia R, van Eimeren T. Impulse control disorders in Parkinson's disease: seeking a roadmap toward a better understanding. Brain Struct Funct 2011;216:289–299.
    1. Colautti L, Iannello P, Silveri MC, Antonietti A. Decision making in Parkinson's disease: an analysis of the studies using the Iowa gambling task. Eur J Neurosci 2021;54:7513–7549.
    1. Craig AD. How do you feel? Interoception: the sense of the physiological condition of the body. Nat Rev Neurosci 2002;3(8):655–666.
    1. Khalsa SS, Adolphs R, Cameron OG, et al. Interoception and mental health: a roadmap. Biol Psychiatry Cogn Neurosci Neuroimaging 2018;3:501–513.