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. 2025 Jun 21:16:20406223251346289.
doi: 10.1177/20406223251346289. eCollection 2025.

Prevalence and determinants of metabolic syndrome among adults living with HIV on first-line antiretroviral treatment in southern Ethiopia: a cross-sectional study

Agete Tadewos Hirigo  1   2 , Daniel Yilma  3   4 , Ayalew Astatkie  5 , Zelalem Debebe  2
Affiliations

Prevalence and determinants of metabolic syndrome among adults living with HIV on first-line antiretroviral treatment in southern Ethiopia: a cross-sectional study

Agete Tadewos Hirigo et al. Ther Adv Chronic Dis. .

Abstract

Background: Antiretroviral therapy (ART) has significantly reduced morbidity and mortality among people living with HIV (PLWH). However, data on the burden of metabolic syndrome (MetS) in sub-Saharan Africa remains limited, particularly following the implementation of universal test-and-treat strategies and the widespread use of integrase inhibitor-based combinations.

Objective: This study aimed to determine the prevalence and associated factors of MetS among adults receiving first-line ART in the Hawassa City Administration, southern Ethiopia.

Design: A cross-sectional study.

Methods: The study was conducted from January 2023 to May 2024, adapting the World Health Organization (WHO) stepwise approach to collect data. All study-relevant data were collected from participants using a pretested structured questionnaire. MetS was defined according to the 2009 harmonized criteria. A binary logistic regression analysis was conducted to identify predictors of MetS, with adjusted odds ratio (aOR) and 95% confidence intervals (CIs).

Results: A total of 450 adults participated in the study, of whom 262 (58.2%) were females. The mean (standard deviation) age of the participants was 41.1(±9.7) years. The prevalence of MetS was 36.4% (95% CI: 32.2-41.6), with low high-density lipoprotein (HDL) cholesterol as the most frequent component observed in 368 (81.8%) participants. Age >50 years (aOR: 2.9; 95% CI: 1.4-6.2), alcohol use (aOR: 2.7; 95% CI: 1.2-6.4), body mass index ⩾25 kg/m² (aOR: 3.7; 95% CI: 1.9-7.1), triglyceride/HDL-cholesterol ratio (aOR: 1.5; 95% CI: 1.3-1.7), family history of hypertension (aOR: 2.1; 95% CI: 1.1-3.8), and high waist-height ratio (aOR: 5.4; 95% CI: 1.8-15.9) were significantly associated with MetS. However, dolutegravir-based first-line regimens were not significantly associated with MetS (p=0.482 for DTG initiation, and p=0.34 for switching to DTG).

Conclusion: The noticeable prevalence of MetS among PLWH highlights its potential to increase cardiovascular risks. Therefore, routine screening of PLWH for components of MetS is essential to reduce the health risks associated with metabolic disorders. As most of the identified risk factors are modifiable, implementing lifestyle interventions is also imperative.

Keywords: HIV; adults; first-line antiretroviral therapy; metabolic syndrome; southern Ethiopia.

Plain language summary

Prevalence and determinants of metabolic syndrome among adults living with HIV on first-line antiretroviral treatment in southern Ethiopia In this study, we investigated the prevalence and determinants of metabolic syndrome (MetS) in adults with HIV on antiretroviral therapy in southern Ethiopia. We presented the prevalence of MetS and its key risk factors in this population. We observed a high prevalence of MetS, with low HDL cholesterol being the most frequently observed component. We also identified that older age, alcohol use, high body mass index, triglyceride/HDL cholesterol ratio, family history of hypertension and increased waist-height ratio were significantly associated with MetS. We found no significant association between dolutegravir-based regimens and MetS. Therefore, we recommend routine screening for MetS components and proactive management of related conditions. In addition, most of the identified risk factors are modifiable, interventions focused on diet, weight management and alcohol use could help reduce MetS in this population. Further studies are required to investigate additional underlying factors and the long-term metabolic risks associated with antiretroviral therapy.

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Figures

Figure 1.
Figure 1.
Overview of the metabolic syndrome components in study participants stratified by sex.
Figure 2.
Figure 2.
Patterns of metabolic syndrome among people with HIV on first-line treatment in relation to age categories.
Figure 3.
Figure 3.
Patterns of metabolic syndrome among people with HIV on first-line treatment in relation to antiretroviral regimens.
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References

    1. Huang P. A comprehensive definition for metabolic syndrome. Dis Model Mech. 2009; 2(5–6): 231–237. - PMC - PubMed
    1. Alberti KGMM, Eckel RH, Grundy SM, et al.; International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; International Association for the Study of Obesity. Harmonizing the metabolic syndrome: a Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 2009; 120: 1640–1645. - PubMed
    1. Lakka H-M, Laaksonen DE, Lakka TA, et al. The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA. 2002; 288(21): 2709–2716. - PubMed
    1. Alberti KG, Eckel RH, Grundy SM, et al. Harmonizing the metabolic syndrome: a Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 2009; 120(16): 1640–1645. - PubMed
    1. Moyo-Chilufya M, Maluleke K, et al. The burden of non-communicable diseases among people living with HIV in Sub-Saharan Africa: a systematic review and meta-analysis. EClinicalMedicine 2023; 65: 102255. - PMC - PubMed

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