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Review
. 2025 Jun 10:47:101146.
doi: 10.1016/j.lana.2025.101146. eCollection 2025 Jul.

Lenacapavir: a potential game changer for HIV prevention in the Americas, if the game is played equitably

Valeria D Cantos  1   2 , Brenda Crabtree Ramírez  3 , Colleen F Kelley  1   2 , Carlos Del Rio  1   2 , Beatriz Grinsztejn  4
Affiliations
Review

Lenacapavir: a potential game changer for HIV prevention in the Americas, if the game is played equitably

Valeria D Cantos et al. Lancet Reg Health Am. .

Abstract

Lenacapavir, a first in class long-acting capsid inhibitor has near 100% efficacy in preventing HIV. As such, it has the potential to curb the rising HIV incidence in Latin America, a region with stark intra- and inter-country PrEP uptake disparities. In this viewpoint, we summarize the current efforts to scale up lenacapavir access globally and the necessary steps to include Latin America in these endeavours.

Keywords: Americas; HIV; Inequities; Lenacapavir; PrEP; Pre-exposure prophylaxis.

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Conflict of interest statement

VDC receives research grants by Gilead Sciences Inc., paid to Emory University. CFK has received research grants to her institution from Gilead Sciences Inc., ViiV, Moderna, Novavax, and Humanigen BC receives research grants to her institution from MSD and ViiV. BC has been a consultant to MSD, GSK and Gilead Sciences Inc. BG has been a consultant for ViiV, Merck, and Gilead Sciences Inc.

References

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