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Review
. 2025 Jun 20;24(2):153.
doi: 10.1007/s40200-025-01671-z. eCollection 2025 Dec.

Meta-analysis of INSR rs2059806 and rs1799817 polymorphisms and their association with polycystic ovarian syndrome in the Asian population

Raphael Enrique Tiongco  1 , Miljun Catacata  1 , Eliezer John Castro  1 , John Ashley Flores  1 , Sofia Alexis Dayrit  1 , Kyll Geonzon  1 , Ma Angelika Tongio  1 , Michael John Dominguez  2
Affiliations
Review

Meta-analysis of INSR rs2059806 and rs1799817 polymorphisms and their association with polycystic ovarian syndrome in the Asian population

Raphael Enrique Tiongco et al. J Diabetes Metab Disord. .

Abstract

Objective: This study determined the association of the insulin receptor (INSR)/NsiI (rs2059806) and INSR/PmlI (rs1799817) single nucleotide polymorphisms (SNPs) with the development of polycystic ovarian syndrome (PCOS) in the Asian population through an updated meta-analysis.

Methods: A comprehensive literature search was conducted using specific search terms related to the SNPs and PCOS. A total of 15 studies were included, involving 1,268 participants for rs2059806 and 3,635 for rs1799817. Data analysis involved genotypic models, odds ratios, and heterogeneity testing using Review Manager 5.4.

Results: Initial results indicated non-significant associations for both SNPs, with high heterogeneity among studies. Funnel plots were used to identify and exclude outlier studies. The post-outlier results showed homogenous but still non-significant associations between the rs2059806 and rs1799817 SNPs with the development of PCOS.

Conclusion: This meta-analysis suggests that the rs2059806 and rs1799817 SNPs are not significantly associated with the development of PCOS in the Asian population. Further longitudinal studies are needed to confirm these findings. These findings highlight the need to explore lifestyle and dietary strategies, especially in the context of insulin resistance not explained by genetic variants.

Keywords: INSR; Meta-analysis; Polycystic ovarian syndrome; rs1799817; rs2059806.

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Conflict of interest statement

Competing interestsThe authors declare no competing interests.

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