Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Published Erratum
. 2025 Oct;22(7):1043-1049.
doi: 10.1007/s13770-025-00740-x.

Correction: Exosomes of Human Fetal Cartilage Progenitor Cells (hFCPCs) Inhibited Interleukin-1β (IL-1β)-Induced Osteoarthritis Phenotype via miR-125b-5p In Vitro

JuHyeok Lee  1 , Jiyoung Lee  1 , Byung Hyune Choi  2
Affiliations
Published Erratum

Correction: Exosomes of Human Fetal Cartilage Progenitor Cells (hFCPCs) Inhibited Interleukin-1β (IL-1β)-Induced Osteoarthritis Phenotype via miR-125b-5p In Vitro

JuHyeok Lee et al. Tissue Eng Regen Med. 2025 Oct.
No abstract available

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Size distribution and concentration of exosomes isolated from hFCPCs and BM-MSCs. Exosomes from hFCPCs and BM-MSCs were purified using ExoQuick-TC (Systems Biosciences). A Images of exosomes isolated from hFCPCs and BM-MSCs were captured using a transmission electron microscope (TEM). B Size distribution of hFCPCs and BM-MSCs exosomes were analyzed using Nanosight analysis. The averaged values from 3 samples are presented, with the hFCPCs exosome data on the left and the BM-MSCs exosome data on the right. C The particle size (left) and concentration (right) of hFCPCs and BM-MSCs exosomes are presented as mean ± SD from 3 samples (n = 3). Mean = average, Mode = most frequent value, and D50 = median values. D The expression of exosome markers (TSG101, Alix and HSP70) was examined by Western blot analysis in hFCPC-Exo and MSC-Exo
Fig. 1
Fig. 1
Size distribution and concentration of exosomes isolated from hFCPCs and BM-MSCs. Exosomes from hFCPCs and BM-MSCs were purified using ExoQuick-TC (Systems Biosciences). A Images of exosomes isolated from hFCPCs and BM-MSCs were captured using a transmission electron microscope (TEM). B Size distribution of hFCPCs and BM-MSCs exosomes were analyzed using Nanosight analysis. The averaged values from 3 samples are presented, with the hFCPCs exosome data on the left and the BM-MSCs exosome data on the right. C The particle size (left) and concentration (right) of hFCPCs and BM-MSCs exosomes are presented as mean ± SD from 3 samples (n = 3). Mean = average, Mode = most frequent value, and D50 = median values. D The expression of exosome markers (TSG101, Alix and HSP70) was examined by Western blot analysis in hFCPC-Exo and MSC-Exo
Fig. 3
Fig. 3
miRNA profile of hFCPCs and BM-MSCs exosomes. The miRNA profile of hFCPC-Exo and MSC-Exo was analyzed for 2588 human miRNAs from the miRNA database (eBiogen, Seoul, Korea). A The number of miRNAs abundant in hFCPC-Exo or MSC-Exo was shown in the Venn diagrams among 2588 total miRNAs (left) or 179 inflammation-related miRNAs (right). B The amount of 167 miRNAs abundant in hFCPC-Exo or MSC-Exo among 179 inflammation-related miRNAs were presented in the scatter plot. Normalized (log2) values of each miRNA was shown together with mean ± SEM. C The pie chart shows the percentage of the 10 selected miRNAs among the miRNAs present in hFCPC-Exo and MSC-Exo, respectively. D The amounts of all miRNAs present in hFCPCExo and MSC-Exo were displayed in a scatter plot. miRNAs present more in hFCPC-Exo than in MSC-Exo are shown in red and the vice versa were shown in green. Dots representing 10 selected miRNAs in C are marked in the scatter plot and shown at high magnification in the boxed insert
Fig. 3
Fig. 3
miRNA profile of hFCPCs and BM-MSCs exosomes. The miRNA profile of hFCPC-Exo and MSC-Exo was analyzed for 2588 human miRNAs from the miRNA database (eBiogen, Seoul, Korea). A The number of miRNAs abundant in hFCPC-Exo or MSC-Exo was shown in the Venn diagrams among 2588 total miRNAs (left) or 179 inflammation-related miRNAs (right). B The amount of 167 miRNAs abundant in hFCPC-Exo or MSC-Exo among 179 inflammation-related miRNAs were presented in the scatter plot. Normalized (log2) values of each miRNA was shown together with mean ± SEM. C The pie chart shows the percentage of the 10 selected miRNAs among the miRNAs present in hFCPC-Exo and MSC-Exo, respectively. D The amounts of all miRNAs present in hFCPCExo and MSC-Exo were displayed in a scatter plot. miRNAs present more in hFCPC-Exo than in MSC-Exo are shown in red and the vice versa were shown in green. Dots representing 10 selected miRNAs in C are marked in the scatter plot and shown at high magnification in the boxed insert
Fig. 6
Fig. 6
Anti-inflammatory effect of hFCPC-Exo and miR-125b-5p on IL-1β signal pathways in chondrocytes. hFCPCs were used to produce an IL-1β-induced OA model in chondrocytes. hFCPCs were transfected with 100 pmol of synthetic miRNA mimic or anti-sense inhibitor of miR125b-5p for 24 h, followed by treatment with IL-1β (10 ng/mL) and/or hFCPC-Exo (10 µg/mL). A The expression of inflammation mediators (IL-1β, MMP13, and ADAMTS-5) was analyzed by RT-PCR. B The expression of cartilage-specific ECMs (ACAN and COL2A1) was analyzed by RT-PCR. In both A and B, data were normalized to GAPDH mRNA levels and presented as mean ± SD from 3 independent experiments (n = 3). Statistical significance was compared for untreated group versus IL-1β group, for IL-1β only group versus the other treatment groups (#), and for exosome group versus miRNA mimic or inhibitor group (*). +/#/*p < 0.05, and ++/**p < 0.01
Fig. 6
Fig. 6
Anti-inflammatory effect of hFCPC-Exo and miR-125b-5p on IL-1β signal pathways in chondrocytes. hFCPCs were used to produce an IL-1β-induced OA model in chondrocytes. hFCPCs were transfected with 100 pmol of synthetic miRNA mimic or anti-sense inhibitor of miR125b-5p for 24 h, followed by treatment with IL-1β (10 ng/mL) and/or hFCPC-Exo (10 µg/mL). A The expression of inflammation mediators (IL-1β, MMP13, and ADAMTS-5) was analyzed by RT-PCR. B The expression of cartilage-specific ECMs (ACAN and COL2A1) was analyzed by RT-PCR. In both A and B, data were normalized to GAPDH mRNA levels and presented as mean ± SD from 3 independent experiments (n = 3). Statistical significance was compared for untreated group versus IL-1β group, for IL-1β only group versus the other treatment groups (#), and for exosome group versus miRNA mimic or inhibitor group (*). +/#/*p < 0.05, and ++/**p < 0.01
See this image and copyright information in PMC

Erratum for

Publication types

LinkOut - more resources