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. 2025 Aug;18(4):970-982.
doi: 10.1007/s12265-025-10643-w. Epub 2025 Jun 24.

Correlation Between NLR to Albumin Ratio and 90-day Prognosis After Treatment for Acute Ischemic Stroke

Peian Liu #  1   2 , Lianhong Ji #  1   2 , Jiale Gan  1   2 , Xinyi Yang  1   2 , Yongxing Deng  1   2 , Junqi Liao  1   2 , Peiyi Mo  1   2 , Qing Zhu  1   2 , Hui Jiang  1   2 , Yunfei Han  1   2 , Zhaoyao Chen  1   2 , Wenlei Li  3   4 , Minghua Wu  5   6 , Yuan Zhu  7   8
Affiliations

Correlation Between NLR to Albumin Ratio and 90-day Prognosis After Treatment for Acute Ischemic Stroke

Peian Liu et al. J Cardiovasc Transl Res. 2025 Aug.

Abstract

The prognostic significance of the neutrophil-to-lymphocyte ratio (NLR) in relation to albumin levels for acute ischemic stroke (AIS) remains unclear. This study examined the correlation between inflammatory markers and nutritional status to predict 90-day outcomes in patients with AIS. A total of 5855 patients with acute cerebral infarction admitted to the Stroke Center at Jiangsu Province Hospital of Chinese Medicine between June 2017 and September 2023 were retrospectively analyzed. The NLR, SIRI, SII, and NLR-ALb were calculated using peripheral venous blood indicators obtained 24 h post-admission. All patients were followed up 90 days after discharge, and their prognosis was evaluated using the modified Rankin Scale (mRS). Logistic regression analysis, receiver operating characteristics, and Kaplan-Meier survival curves were used to explore the association between inflammatory markers and 90-day outcomes in patients with AIS. In conclusion, higher levels of NLR, SIRI, SII, and the NLR-ALB ratio are associated with poor outcomes following AIS.

Keywords: Acute ischemic stroke; Inflammation; Neurological outcomes; Neutrophil-to-lymphocyte ratio; Serum albumin.

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Conflict of interest statement

Declarations. Ethics Approval: Study approval statement: This study protocol was reviewed and approved by Institutional Review Board of Affiliated Hospital of Nanjing University of Chinese Medicine (Jiangsu Province Hospital of Chinese Medicine), with an approval number of 2017NL-012–01. Informed consent was waived because of the retrospective design. During the study, patient data confidentiality and compliance with the Declaration of Helsinki were followed. Competing interests: The authors declare that they have no conflict of interest.

References

    1. Herpich F, Rincon F. Management of acute ischemic stroke. Crit Care Med. 2020;48(11):1654–63. - PubMed - PMC
    1. Gao Y, Jiang B, Sun H, et al. The burden of stroke in China: Results from a nationwide population-based epidemiological survey. PLoS ONE. 2018;13(12):e0208398. - PubMed - PMC
    1. Powers WJ, Rabinstein AA, Ackerson T, et al. Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: a guideline for healthcare professionals from the American heart association/american stroke association. Stroke. 2019;50(12):e344–418. - PubMed
    1. Simonsen CZ, Schmitz ML, Madsen MH, et al. Early neurological deterioration after thrombolysis: Clinical and imaging predictors. Int J Stroke. 2016;11(7):776–82. - PubMed
    1. Zhang T, Fu S, Cao X, et al. Correlation of peripheral blood inflammatory indicators to prognosis after intravenous thrombolysis in acute ischemic stroke: A retrospective study. Int J Gen Med. 2024;17:985–96. - PubMed - PMC

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