Requirements and considerations for effective implementation of integrated One Health antimicrobial resistance research

Dominic Poulin-Laprade¹, Jordyn Broadbent², Damien Biot-Pelletier³, Susanne Kraemer⁴, Emma J Griffiths⁵, Ayush Kumar⁶, Xian-Zhi Li⁷, Catherine D Carrillo⁸, Rahat Zaheer⁹, Tim A McAllister⁹, Sigrun Kullik¹⁰, Ernesto Liebana¹¹, Nicole Ricker¹², Alexandra Langlois¹, Richard J Reid-Smith¹³, Sébastien P Faucher¹⁴, Gabriela Flores-Vargas¹⁵, Emilie Bédard¹⁶, J Kimberley Summers¹⁷, Veronica Jarocki^{18

19}, Thanaporn Thongthum²⁰, Carolee A Carson¹³

Affiliations

¹ Sherbrooke Research and Development Center, Agriculture and Agri-Food Canada, Sherbrooke, QC, Canada.
² Watershed Hydrology and Ecology Research Division, Environment and Climate Change Canada, Saskatoon, SK, Canada.
³ Centre d'expertise en analyse environnementale du Québec, Ministère de l'Environnement, de la Lutte contre les changements climatiques, de la Faune et des Parcs, Québec, QC, Canada.
⁴ Aquatic Contaminants Research Division, Environment and Climate Change Canada, Montreal, QC, Canada.
⁵ Centre for Infectious Disease genomics and One Health (CIDGOH), Faculty of Health Sciences, Simon Fraser University, Vancouver, BC, Canada.
⁶ Department of Microbiology, University of Manitoba, Winnipeg, MB, Canada.
⁷ Veterinary Drugs Directorate, Health Canada, Ottawa, ON, Canada.
⁸ Ottawa Research and Development Centre, Canadian Food Inspection Agency, Ottawa, ON, Canada.
⁹ Lethbridge Research and Development Centre, Agriculture and Agri-Food Canada, Lethbridge, AB, Canada.
¹⁰ Antimicrobial Resistance Task Force, Public Health Agency of Canada, Ottawa, ON, Canada.
¹¹ BIOHAW Unit, European Food Safety Authority (EFSA), Parma, Italy.
¹² Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.
¹³ Centre for Foodborne, Environmental and Zoonotic Infectious Diseases, Public Health Agency of Canada, Guelph, ON, Canada.
¹⁴ Department of Natural Resource Sciences, Faculty of Agriculture and Environmental Sciences, McGill University, Montreal, QC, Canada.
¹⁵ Centre de Recherche de l'Hôpital Maisonneuve-Rosemont, Montréal, QC, Canada.
¹⁶ Civil Engineering Department, Polytechnique Montréal, QC, Canada.
¹⁷ Organisms and Ecosystems, Earlham Institute, Norwich, UK.
¹⁸ Australian Institute of Microbiology and Infection, University of Technology Sydney, Sydney, NSW, Australia.
¹⁹ Cooperative Research Centre for Solving Antimicrobial resistance in Agribusiness, Food and Environments, Mawson Lakes, South Australia, Australia.
²⁰ Department of Environmental and Global Health, College of Public Health and Health Professions, and Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA.

PMID: 40554807
DOI: 10.1139/cjm-2024-0194

Review

Requirements and considerations for effective implementation of integrated One Health antimicrobial resistance research

Dominic Poulin-Laprade et al. Can J Microbiol. 2025.

. 2025 Jan 1:71:1-17.

doi: 10.1139/cjm-2024-0194.

Authors

Affiliations

¹ Sherbrooke Research and Development Center, Agriculture and Agri-Food Canada, Sherbrooke, QC, Canada.
² Watershed Hydrology and Ecology Research Division, Environment and Climate Change Canada, Saskatoon, SK, Canada.
³ Centre d'expertise en analyse environnementale du Québec, Ministère de l'Environnement, de la Lutte contre les changements climatiques, de la Faune et des Parcs, Québec, QC, Canada.
⁴ Aquatic Contaminants Research Division, Environment and Climate Change Canada, Montreal, QC, Canada.
⁵ Centre for Infectious Disease genomics and One Health (CIDGOH), Faculty of Health Sciences, Simon Fraser University, Vancouver, BC, Canada.
⁶ Department of Microbiology, University of Manitoba, Winnipeg, MB, Canada.
⁷ Veterinary Drugs Directorate, Health Canada, Ottawa, ON, Canada.
⁸ Ottawa Research and Development Centre, Canadian Food Inspection Agency, Ottawa, ON, Canada.
⁹ Lethbridge Research and Development Centre, Agriculture and Agri-Food Canada, Lethbridge, AB, Canada.
¹⁰ Antimicrobial Resistance Task Force, Public Health Agency of Canada, Ottawa, ON, Canada.
¹¹ BIOHAW Unit, European Food Safety Authority (EFSA), Parma, Italy.
¹² Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.
¹³ Centre for Foodborne, Environmental and Zoonotic Infectious Diseases, Public Health Agency of Canada, Guelph, ON, Canada.
¹⁴ Department of Natural Resource Sciences, Faculty of Agriculture and Environmental Sciences, McGill University, Montreal, QC, Canada.
¹⁵ Centre de Recherche de l'Hôpital Maisonneuve-Rosemont, Montréal, QC, Canada.
¹⁶ Civil Engineering Department, Polytechnique Montréal, QC, Canada.
¹⁷ Organisms and Ecosystems, Earlham Institute, Norwich, UK.
¹⁸ Australian Institute of Microbiology and Infection, University of Technology Sydney, Sydney, NSW, Australia.
¹⁹ Cooperative Research Centre for Solving Antimicrobial resistance in Agribusiness, Food and Environments, Mawson Lakes, South Australia, Australia.
²⁰ Department of Environmental and Global Health, College of Public Health and Health Professions, and Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA.

PMID: 40554807
DOI: 10.1139/cjm-2024-0194

Abstract

The One Health (OH) approach recognizes the interconnectedness of the health of people, animals, plants/crops and ecosystems, and is central to addressing antimicrobial resistance (AMR). The 7th Environmental Dimension of Antimicrobial Resistance Conference (EDAR7), held in Montreal in May 2024, exemplified this approach by convening international experts and stakeholders to discuss AMR research and policy progress. EDAR7 workshop #8 focused on (1) barriers to establishing effective OH AMR research programs, (2) gaps in OH AMR research priorities, and (3) potential solutions/approaches or "tools" to ensure programs develop in accordance with OH principles and generate insightful data that maximizes limited resources. Key workshop outcomes included identifying critical principles for OH AMR research programs and highlighting the pivotal role of sustainable data management strategies. Additionally, the importance of considering AMR policy and risk assessment needs when planning and designing research was emphasized. Discussions explored specific tools and approaches that support the standardized and harmonized collection and analysis of data, and associated challenges of integrating genomics data into current risk assessments and models. Synthesis of the workshop's discussions outlined critical considerations that interdisciplinary OH AMR research programs and networks should prioritize to enhance the impact of their outputs.

Keywords: One Health; antimicrobial resistance; environment; genomics; transdisciplinary.

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Conflict of interest statement

The authors declare there are no competing interests.

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Requirements and considerations for effective implementation of integrated One Health antimicrobial resistance research

Affiliations

Requirements and considerations for effective implementation of integrated One Health antimicrobial resistance research

Authors

Affiliations

Abstract

Conflict of interest statement

Publication types

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LinkOut - more resources

Full Text Sources

Medical